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HIV/AIDS

Carol H. Hungerford, DO and Pamela R. Hughes, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • HIV is a retrovirus (subgroup lentivirus) that integrates into CD4 T lymphocytes, altering cell-mediated immunity and causing cell death, severe immunodeficiency, opportunistic infec...

DIAGNOSIS

  • Acute retroviral syndrome: CD4 lymphocyte count declines with increase in viral load 1 to 4 weeks after transmission; confirmed by high-HIV RNA in the absence of HIV antibody

  • Acute retroviral...

TREATMENT

  • Initiate ART in patients meeting eligibility requirements. Select/change regimens based on resistance testing.

  • Consider dosing frequency, pill burden, adverse toxic effect profiles, comorbidi...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • HIV RNA (viral load) 2 to 8 weeks after starting therapy and repeated every 3 to 6 months until suppressed (3)

  • Monitor HIV RNA, CD4, and CBC ever...

REFERENCES

1
Centers for Disease Control and Prevention. HIV/AIDS basic statistics. https://www.cdc.gov/hiv/basics/statistics.html. Updated June 26, 2018. Accessed September 8, 2018. https://www.cdc.go...

ADDITIONAL READING

CODES

ICD10

  • Z21 Asymptomatic human immunodeficiency virus infection status

  • B20 Human immunodeficiency virus [HIV] disease

  • R75 Inconclusive laboratory evidence of human immunodef virus

  • Z20.6 Contact w and ...

CLINICAL PEARLS

  • Acute HIV seroconversion illness mimics mononucleosis and is characterized by fever, sore throat, adenopathy, myalgias, and rash.

  • Transmitted drug resistance is increasing. Evaluate for...

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