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Hodgkin Lymphoma

Rory M. Shallis, MD and John L. Reagan, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

Historical background: 
  • Described in 1832 by Thomas Hodgkin in “On some morbid appearance of the absorbent glands and spleen”

  • First neoplasm to be (i) defined by cytologic grounds base...

DIAGNOSIS

HISTORY

  • Asymptomatic lymphadenopathy (cervical/supraclavicular)

  • Pel-Ebstein (cyclic) fever

  • Constitutional symptoms: night sweats, weight loss, fatigue, anorexia

  • Alcohol-induced pain

  • Pruritus

PHYSICAL EXAM

TREATMENT

  • Ann Arbor staging with Cotswold modification

    • Stage I: single lymph node or of a single extralymphatic organ or site

    • Stage II: ≥2 lymph node regions on the same side of diaphragm alone or wit...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • During therapy: CBC, nutrition, and hydration

  • Restage with PET after 2 to 4 cycles of chemotherapy: sensitive prognostic indicator

  • Posttreatment m...

REFERENCES

1
Barrington SF, Kirkwood AA, Franceschetto A, et al. PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study. Blood.  2016;1...

ADDITIONAL READING

  • American Cancer Society. American Cancer Society Recommendations for Early Breast Cancer Detection in Women without Breast Symptoms. Atlanta, GA: American Cancer Society; 2013.

  • Cen...

CODES

ICD10

  • C81.90 Hodgkin lymphoma, unspecified, unspecified site

  • C81.91 Hodgkin lymphoma, unsp, lymph nodes of head, face, and neck

  • C81.92 Hodgkin lymphoma, unspecified, intrathoracic lymph nodes

  • C81.95...

CLINICAL PEARLS

  • Neoplastic disease of lymphatics

  • RS cells of monoclonal lymphoid B-cell origin within inflammatory background of lymphocytes

  • Two subtypes: CHL 95% of cases and NLPHL 5% of cases

  • Cure rate...

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