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Hodgkin Lymphoma

John L. Reagan, MD Reviewed 06/2020
 


BASICS

DESCRIPTION

Historical background: 
  • Described in 1832 by Thomas Hodgkin in “On some morbid appearance of the absorbent glands and spleen”

  • First neoplasm to be (i) defined by cytologic grounds base...

DIAGNOSIS

HISTORY

  • Asymptomatic lymphadenopathy (cervical/supraclavicular)

  • Pel-Ebstein (cyclic) fever

  • Constitutional symptoms: night sweats, weight loss, fatigue, anorexia

  • Alcohol-induced pain

  • Pruritus

PHYSICAL EXAM

TREATMENT

  • Ann Arbor staging with Cotswold modification

    • Stage I: single lymph node or of a single extralymphatic organ or site

    • Stage II: ≥2 lymph node regions on the same side of diaphragm alone or with ...

ONGOING CARE

Patients treated with ABVD become neutropenic. Treatment is continued despite neutropenia with no clear increased risk of infection with or without growth factors. 

FOLLOW-UP RECOMMENDATIONS

REFERENCES

1
Barrington SF, Kirkwood AA, Franceschetto A, et al. PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study. Blood.  2016;1...

ADDITIONAL READING

  • American Cancer Society. American Cancer Society Recommendations for Early Breast Cancer Detection in Women without Breast Symptoms. Atlanta, GA: American Cancer Society; 2013.

  • Cen...

CODES

ICD10

  • C81.90 Hodgkin lymphoma, unspecified, unspecified site

  • C81.91 Hodgkin lymphoma, unsp, lymph nodes of head, face, and neck

  • C81.92 Hodgkin lymphoma, unspecified, intrathoracic lymph nodes

  • C81.95...

CLINICAL PEARLS

  • Neoplastic disease of lymphatics

  • RS cells of monoclonal lymphoid B-cell origin within inflammatory background of lymphocytes

  • Two subtypes: CHL 95% of cases and NLPHL 5% of cases

  • CHL cure ...

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