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Hypercholesterolemia

Elizabeth Kardas, MD and Jeremy Golding, MD, FAAFP Reviewed 06/2018
 


BASICS

DESCRIPTION

  • High cholesterol is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD).

  • Lipoprotein subtypes:

    • Low-density lipoproteins (LDL): atherogenic; primary target of...

DIAGNOSIS

Screening recommendations: 
  • U.S. Preventive Services Task Force (USPSTF) (1)[A]: TC and HDL cholesterol (HDL-C) every 5 years

    • All men age ≥35 years

    • Men aged 20 to 35 years and women aged 20 t...

TREATMENT

ALERT

2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines no longer recommend treatment to an LDL goal. ACC/AHA, NICE, and USPSTF guidelines recomm...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Exercise: sustained exercise for 30 minutes, 3 to 4 times per week: increases HDL, lowers TC, and helps control weight 

Patient Monitoring

  • Initially, lipid panel in...

REFERENCES

1
U.S. Preventive Services Task Force. Lipid disorders in adults (cholesterol, dyslipidemia): screening. http://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/lipid-d...

ADDITIONAL READING

Taylor F, Huffman MD, Macedo AF, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev.  2013;(1):CD004816. [View Abstract on OvidMed...

SEE ALSO

  • Hypothyroidism, Adult

CODES

ICD10

E78.0 Pure hypercholesterolemia 

ICD9

272.0 Pure hypercholesterolemia 

SNOMED

  • 13644009 Hypercholesterolemia (disorder)

  • 398036000 Familial hypercholesterolemia (disorder)

  • 238076009 primary hyperch...

CLINICAL PEARLS

  • Hypercholesterolemia is a significant risk factor for ASCVD, but ASCVD is a multifactorial disease with many different risk factors.

  • Diet and exercise should be tried before pharmaceuti...

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