Hypereosinophilic syndrome (HES): a group of disorders characterized by an overproduction of eosinophils that subsequently infiltrate and damage multiple organs
Hypereosinophilia (HE)...
A persistently elevated eosinophil count >1.5 × 109 cells/L on two examinations at least 1 month apart and/or tissue HE (2)[C]
Eosinophil-mediated organ damage in which other potential ca...
Consider FIP1L1-PDGFRA (F/P) transcript status.
Initial treatment involves a trial of glucocorticoids alone in all patients except those with F/P+ (2)[B].
F/P+HES
Tyrosine kinase in...
Weekly CBC on treatment; longer when stable
L-HES: increa...
Curtis C, Ogbogu P. Hypereosinophilic syndrome. Clin Rev Allergy Immunol. 2016;50(2):240–251. [View Abstract on OvidMedline] ...
HES encompasses a group of diseases with eosinophils >1,500/μL and end-organ damage without an identifiable secondary cause.
F/P+ transcript status helps guide the course of treatmen...
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