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Hyperparathyroidism

Juan Perez, D.O. Reviewed 04/2024
 


BASICS

DESCRIPTION

Excess production of parathyroid hormone (PTH) 
  • Primary hyperparathyroidism (HPT): intrinsic parathyroid gland dysfunction resulting in excessive secretion of PTH with a lack of respo...

DIAGNOSIS

HISTORY

History of present illness 
  • Almost 80% of patients are asymptomatic.

  • Kidney stones (15–20%)

  • Osteitis fibrosa cystica (<5%) characterized by subperiosteal resorption of phalanges, tape...

TREATMENT

MEDICATION

  • Primary HPT: Operative management is curative; indications for surgical intervention are mentioned below. For those awaiting or unable to have surgery:

    • Bisphosphonates (alendronate)...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Asymptomatic patients with primary HPT require serial monitoring of calcium and PTH. 

Patient Monitoring

In patients with primary HPT who are asymptomatic, measurem...

REFERENCES

1
Bilezikian  JP, Brandi  ML, Eastell  R, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth Internat...

ADDITIONAL READING

SEE ALSO

  • Bilezikian JP. Primary hyperparathyroidism.  J Clin Endocrinol Metab. 2018;103(11):3993-4004. doi:10.1210/jc.2018-01225

  • ...

CODES

ICD10

  • E21.3 Hyperparathyroidism, unspecified

  • N25.81 Secondary hyperparathyroidism of renal origin

  • E21.1 Secondary hyperparathyroidism, not elsewhere classified

  • E21.0 Primary hyperparathyroidism

  • E21.2...

CLINICAL PEARLS

  • 80% of patients with primary HPT are asymptomatic.

  • HPT is often detected by an incidental finding of hypercalcemia on a routine serum chemistry analysis.

  • Classic symptoms of HPT include ...

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