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Hypertriglyceridemia

S. Lindsey Clarke, MD, FAAFP Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Hypertriglyceridemia (HTG) is a common form of dyslipidemia characterized by an excess fasting plasma concentration of triglycerides (TGs).

    • TGs are fatty molecules that occur naturall...

DIAGNOSIS

HISTORY

  • Usually asymptomatic

  • Patients with chylomicronemia syndrome can have memory loss, headache, vertigo, dyspnea, and paresthesias.

  • Pancreatitis: epigastric pain, nausea, and vomiting

  • Assess...

TREATMENT

GENERAL MEASURES

  • Cardiovascular risk reduction through LDL lowering should be prioritized over TG lowering unless patient is at risk for pancreatitis because of very high TG (≥500 mg/dL) 1[C]...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

2 months after initiation or modification of therapy (repeat fasting lipid profile) 

Patient Monitoring

  • Fasting lipid profile q6–12mo

  • Maintain TG <1,000 mg/dL to ...

REFERENCES

1
Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation.  2011;123(20):2292–2333.
2
Wa...

ADDITIONAL READING

  • Jellinger PS, Handelsman Y, Rosenblit PD, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia an...

CODES

ICD10

E78.1 Pure hyperglyceridemia 

ICD9

272.1 Pure hyperglyceridemia 

SNOMED

  • 302870006 Hypertriglyceridemia (disorder)

  • 238083002 Primary hypertriglyceridemia (disorder)

  • 238087001 secondary hypertrigly...

CLINICAL PEARLS

  • HTG is a risk factor for pancreatitis at levels ≥1,000 mg/dL and for coronary artery disease at levels ≥200 mg/dL.

  • Diet and exercise are first-line interventions for all patients who ha...

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