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Hypertriglyceridemia

S. Lindsey Clarke, MD, FAAFP Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Hypertriglyceridemia (HTG) is a common form of dyslipidemia characterized by an excess fasting plasma concentration of triglycerides (TG).

    • TG are fatty molecules that occur naturall...

DIAGNOSIS

HISTORY

  • Usually asymptomatic

  • Patients with chylomicronemia syndrome can have memory loss, headache, vertigo, dyspnea, and paresthesias.

  • Pancreatitis: epigastric pain, nausea, and vomiting

  • Assess...

TREATMENT

GENERAL MEASURES

  • Cardiovascular risk reduction through LDL lowering should be prioritized over TG lowering unless patient is at risk for pancreatitis because of very high TG (≥500 mg/dL) (1)[...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

2 months after initiation or modification of therapy (repeat fasting lipid profile) 

Patient Monitoring

  • Fasting lipid profile q6–12mo

  • Maintain TG <1,000 mg/dL to ...

REFERENCES

1
Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation.  2011;123(20):2292–2333. [...

ADDITIONAL READING

Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab.  2012;...

SEE ALSO

  • Hypercholesterolemia; Pancreatitis, Acute

  • Algorithm: Hypertriglyceridemia

CODES

ICD10

E78.1 Pure hyperglyceridemia 

ICD9

272.1 Pure hyperglyceridemia 

SNOMED

  • 302870006 Hypertriglyceridemia (disorder)

  • 238083002 Primary hypertriglyceridemia (disorder)

  • 238087001 secondary hypertrigly...

CLINICAL PEARLS

  • HTG is a risk factor for pancreatitis at levels ≥1,000 mg/dL and for coronary artery disease at levels ≥200 mg/dL.

  • Diet and exercise are first-line interventions for all patients who ha...

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