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Hypoparathyroidism

Carrie Valenta, FHM, FACP, MD Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Deficient or absent secretion of parathyroid hormone (PTH), a major hormone regulator of serum calcium and phosphorus levels in the body (1)

  • Acute hypoparathyroidism: tetany that is ...

DIAGNOSIS

HISTORY

Often asymptomatic; ask about previous neck trauma or surgery, head or neck irradiation, family history of hypocalcemia, or presence of other autoimmune endocrinopathies. 
  • Cardinal cli...

TREATMENT

GENERAL MEASURES

  • Monitor ECG during calcium repletion.

  • Maintenance therapy: may require lifelong treatment with calcium and calcitriol

    • Maintain serum calcium in low normal range: 8 to 8.5 mg/d...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Goal is a total corrected serum calcium level in low normal range (8.0 to 8.5 mg/dL or 2.00 to 2.12 mmol/L), 24-hour urine calcium <300 mg, a...

REFERENCES

1
Abate  E, Clarke  B. Review of hypoparathyroidism. Front Endocrinol (Lausanne).  2017;7:172. [View Abstract on OvidMedline]
2
...

ADDITIONAL READING

  • Bollerslev  J, Rejnmark  L, Marcocci  C, et al. European Society of Endocrinology clinical guideline: treatment of chronic hypoparathyroidism in adults. E...

CODES

ICD10

  • E20 Hypoparathyroidism

  • E20.8 Other hypoparathyroidism

  • E20.0 Idiopathic hypoparathyroidism

  • E20.9 Hypoparathyroidism, unspecified

  • E20.1 Pseudohypoparathyroidism

  • E89.2 Postprocedural hypoparathyroi...

CLINICAL PEARLS

Often asymptomatic; consider if hypocalcemic with fatigue and circumoral or distal extremity paresthesias. 
  • Correct the serum calcium level for albumin level.

  • Monitor calcium after thyro...

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