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IgA Nephropathy

Niyomi De Silva, MD, Hasan Syed, MD and Afsha Rais, MD Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Renal parenchymal damage and dysfunction defined by deposition of IgA in glomerular mesangium

  • Most common form of glomerulonephritis in the world

  • Significant contributor to the inciden...

DIAGNOSIS

HISTORY

40–50% of patients present with painless recurrent episodes of macroscopic hematuria concurrent to or immediately after upper respiratory infections (1). 

PHYSICAL EXAM

  • Hypertension

  • Ede...

TREATMENT

MEDICATION

First Line

  • Use angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) to achieve blood pressure (BP) target of 125/75 mm Hg and decrease proteinuria ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Patients with mild proteinuria (≤500 mg/day), normal renal function, and normal BP may be treated conservatively with regular follow-up at 6-month intervals.

  • Patie...

REFERENCES

1
Manno  C, Torres  DD, Rossini  M, et al. Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nep...

ADDITIONAL READING

  • Floege  J, Eitner  F. Current therapy for IgA nephropathy. J Am Soc Nephrol.  2011; 22(10): 1785– 1794.

  • ...

CODES

ICD10

N02.8 Recurrent and persistent hematuria with other morphologic changes 

SNOMED

  • 236407003 Immunoglobulin A nephropathy (disorder)

  • 445404003 familial immunoglobulin A nephropathy (disorder)

  • 2823...

CLINICAL PEARLS

  • IgAN is the most common cause of glomerulonephritis in the world.

  • 40–50% of patients present with painless recurrent episodes of macroscopic hematuria concurrent to or immediately after...

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