IgA Nephropathy

Niyomi De Silva, MD, Li Wan, M.D. and Afsha Rais Kaisani, FAAFP, MD Reviewed 04/2024

BASICS

IgA nephropathy (IgAN) is an autoimmune disease that occurs when immunoglobulin A (IgA) deposits build up in the kidneys, leading to inflammation and damage.

DESCRIPTION

Renal parenchymal damag...

DIAGNOSIS

HISTORY

40–50% of patients present with painless recurrent episodes of macroscopic hematuria concurrent to or immediately after upper respiratory infections (1). Thirty to 40% of patients ha...

TREATMENT

GENERAL MEASURES

Blood pressure control and reduction of proteinuria by inhibition of the renin-angiotensin system (2,3)
Lifestyle modifications such as dietary sodium restriction, smoking ce...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients with mild proteinuria (≤500 mg/day), normal renal function, and normal BP may be treated conservatively with regular follow-up at 6-month intervals.
Patie...

REFERENCES

Manno C, Torres DD, Rossini M, et al. Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nep...

CODES

ICD10

N02.8 Recurrent and persistent hematuria with other morphologic changes

SNOMED

236407003 Immunoglobulin A nephropathy (disorder)
445404003 familial immunoglobulin A nephropathy (disorder)
2823...

CLINICAL PEARLS

IgAN is the most common cause of glomerulonephritis in the world.
40–50% of patients present with painless recurrent episodes of macroscopic hematuria concurrent to or immediately after...

Subscribe to Access Full Content

START 10-DAY FREE TRIAL

Subscribe Now

Forgot password?

Enter an Access Code

GET CME/CE