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Immunodeficiency Diseases

Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Immunodeficiency can be either primary or secondary (acquired). There are numerous causes; each may lead to increased risk of infections, autoimmune diseases, and cancers (1).

  • Primary...

DIAGNOSIS

HISTORY

  • A complete personal and family history are central to correct diagnosis. Recurrent respiratory infections are the most common clinical manifestations (1).

  • 10 signs of possible primary ...

TREATMENT

GENERAL MEASURES

  • Avoid live viral vaccines in patients with severe cellular or antibody immunodeficiencies. This includes varicella, zoster, measles, mumps, rubella, oral polio, smallpox, bac...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Varies according to deficiency

  • Recurrence of infections or failure to fully treat current infection

  • Decline in respiratory function

  • Patients on IgG...

REFERENCES

1
Bonilla FA, Khan DA, Ballas ZK, et al; for Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asth...

ADDITIONAL READING

  • Bousfiha AA, Jeddane L, Ailal F, et al. Primary immunodeficiency diseases worldwide: more common than generally thought. J Clin Immunol.  2013;33(1):1–7. [View Abstract on Ovid...

CODES

ICD10

  • D84.9 Immunodeficiency, unspecified

  • D80.9 Immunodeficiency with predominantly antibody defects, unspecified

  • D80.2 Selective deficiency of immunoglobulin A [IgA]

  • D83.9 Common variable immunodef...

CLINICAL PEARLS

  • Patients with immunodeficiencies may appear deceptively healthy, belying the fact that they have an underlying attenuated inflammatory response.

  • Patients with humoral deficiencies may h...

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