Acute lymphoblastic leukemia (ALL) in adults is the result of a clonal proliferation, survival, and impaired differentiation of immature lymphocytes. The World Health Organization (W...
Symptoms arise from sequelae of bone marrow suppression and/or from leukemic cell organ infiltration.
B symptoms: fever, weight loss, night sweats
Anemia: fatigue, shortness of breath, ...
Three phases to treatment:
Induction + CNS prophylaxis
Consolidation
Prolonged maintenance
Treatment for initial induction and relapse is changing based on Ph receptor status and...
Requires inpatient admission during induction CTX for continuous infusion and monitoring of metabolic and infectious com...
C91.00 Acute lymphoblastic leukemia not having achieved remission
C91.01 Acute lymphoblastic leukemia, in remission
C91.02 Acute lymphoblastic leukemia, in relapse
204.00 Acute lymphoid le...
The diagnosis of ALL is based on the presence of ≥20% (NCCN) or 25% (WHO) lymphoblasts or characteristic mutations in the bone marrow.
Hyper-CVAD is still the main therapy; however, new...
Sign up for a 10-day FREE Trial now and receive full access to all content.