Acute lymphoblastic leukemia (ALL) in adults is the result of a clonal proliferation, survival, and impaired differentiation of immature lymphocytes. The World Health Organization (W...
Symptoms arise from sequelae of bone marrow suppression and/or from leukemic cell organ infiltration.
B symptoms: fever, weight loss, night sweats
Anemia: fatigue, shortness of breath, ...
Three phases to treatment:
Induction + CNS prophylaxis
Consolidation
Prolonged maintenance
Multi-drug approach to eradicate disease, restore normal hematopoiesis, and prevent r...
Requires inpatient admission during induction CTX for continuous infusion and monitoring of metabolic and infectious com...
C91.00 Acute lymphoblastic leukemia not having achieved remission
C91.01 Acute lymphoblastic leukemia, in remission
C91.02 Acute lymphoblastic leukemia, in relapse
204.00 Acute lymphoid le...
The diagnosis of ALL is based on the presence of ≥20% (NCCN) or 25% (WHO) lymphoblasts, or characteristic mutations in the bone marrow.
Adult patients with ALL suffer higher mortality r...
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