Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive accumulation of mature but functionally incompetent lymphocytes.
CLL should be distinguished...
Insidious onset. It is not unusual for CLL to be discovered incidentally (up to 40% of patients are asymptomatic at the time of diagnosis).
Others may have the following symptoms:
B sym...
Patients with CLL with frequent infections associated with hypogammaglobulinemia are likely to benefit from infusions of intravenous immunoglobulin (IVIG).
Genetic risk strati...
CBC with differential (lymphocytosis), LDH, and β2-microglobulin every 3 to 6 months
Phy...
Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med. 2005;352(8):804–815.
National Comprehensive Cancer Network guidelines: http://www.nccn.org/
Shanafe...
C91.12 Chronic lymphocytic leukemia of B-cell type in relapse
C91.11 Chronic lymphocytic leukemia of B-cell type in remission
C91.10 Chronic lymphocytic leukemia of B-cell type not having ach...
CLL is the most common form of leukemia in adults in the United States.
CLL primarily affects elderly individuals, median age of diagnosis being 70 years. Incidence continues to rise in...
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