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Leukemia, Chronic Lymphocytic

Jan Cerny, PhD, MD Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive accumulation of mature but functionally incompetent lymphocytes.

  • Based on percentage of prol...

DIAGNOSIS

HISTORY

  • Insidious onset. CLL is often discovered incidentally (up to 40% of patients are asymptomatic at the time of diagnosis).

  • Others may have the following symptoms:

    • B symptoms: fevers, nigh...

TREATMENT

GENERAL MEASURES

  • Patients with frequent infections due to hypogammaglobulinemia are likely to benefit from infusions of intravenous immunoglobulin (IVIG).

  • Genetic Risk Stratification in therap...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Patients with low-risk CLL and/or patients in remission: 
  • CBC with differential (lymphocytosis), LDH, and β2-microglobulin every 3 to 6 months

  • Phy...

REFERENCES

1
Yan H, Tian S, Kleinstern G, et al. Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci. Hum Mol Genet. 2020;29(16):2761-2774. 
2
Burger J....

ADDITIONAL READING

National Comprehensive Cancer Network. National Comprehensive Cancer Network guidelines. http://www.nccn.org.  

CODES

ICD10

  • C91.12 Chronic lymphocytic leukemia of B-cell type in relapse

  • C91.11 Chronic lymphocytic leukemia of B-cell type in remission

  • C91.10 Chronic lymphocytic leukemia of B-cell type not having ach...

CLINICAL PEARLS

  • CLL is the most common form of leukemia in adults in the United States.

  • CLL primarily affects elderly individuals, median age of diagnosis being 70 years. Incidence continues to rise in...

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