Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized by a progressive accumulation of mature but functionally incompetent lymphocytes.
Based on percentage of prol...
Insidious onset. CLL is often discovered incidentally (up to 40% of patients are asymptomatic at the time of diagnosis).
Others may have the following symptoms:
B symptoms: fevers, nigh...
Patients with frequent infections due to hypogammaglobulinemia are likely to benefit from infusions of intravenous immunoglobulin (IVIG).
Genetic Risk Stratification in therap...
CBC with differential (lymphocytosis), LDH, and β2-microglobulin every 3 to 6 months
Phy...
C91.12 Chronic lymphocytic leukemia of B-cell type in relapse
C91.11 Chronic lymphocytic leukemia of B-cell type in remission
C91.10 Chronic lymphocytic leukemia of B-cell type not having ach...
CLL is the most common form of leukemia in adults in the United States.
CLL primarily affects elderly individuals, median age of diagnosis being 70 years. Incidence continues to rise in...
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Cleaved cell (butt) CELL TYPE: Lymphocyte DESCRIPTION: Small, mature lymphocyte with cleaved nucleus CLINICAL CONDITIONS: Pertussis (Whooping cough) Lymphoma CLL
Cleaved cell (butt) CELL TYPE: Lymphocyte DESCRIPTION: Small, mature lymphocyte with cleaved nucleus CLINICAL CONDITIONS: Per...
Chronic Lymphocytic Leukemia (CLL) White cells Increased to 20 to 200 X 10 9 /L Absolute lymphocytosis Typical, small lymphocytes with a hypermature appearing nucleus Smudge cells present Less than 10% prolymphocytes Larger cells may be seen in Richters Syndrome Red cells Normocytic, normochromic anemia Platelets Normal Often decreased with disease progression Bone marrow Replacement by lymphocytes Less than 10% prolymphocytes Immunophenotype CD5, CD19, CD23, CD79a...
Chronic Lymphocytic Leukemia (CLL) White cells Increased to 20 to 200 X 10 9 /L Absolute lymphocytosis Typical, small lymphocytes with...