Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm characterized by clonal proliferation of myeloid precursors in the bone marrow with continuing differentiation int...
Chronic phase: fatigue, weight loss, night sweats, abd...
TKIs (e.g., imatinib) provide durable, long-term control of disease.
The response to TKIs is assessed at specific time points from the beginning of treatment and is categorized as f...
Frequency depends on stage at presentation and response to first-line therapy.
Although splenomegaly persists, avoid contact sports or trauma to abdomen.
C92.2 Atypical chronic myeloid leukemia, BCR/ABL-negative
C92.12 Chronic myeloid leukemia, BCR/ABL-positive, in relapse
C92.22 Atypical chronic myeloid leukemia, BCR/ABL-negative, in relapse
C...
CML belongs to the myeloproliferative disorders group.
The gold standard for diagnosis of CML is detection of the Philadelphia chromosome or its products, BCR-ABL mRNA, and fusion prote...
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Wright-Giemsa stain: chronic myelocytic leukemia (CML) with leukocytosis; 250x