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Leukoplakia, Oral

Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Oral leukoplakia is a white plaque or patches on the oral mucosa, generally precancerous.

  • System(s) affected: gastrointestinal

  • Hyperplasia of squamous epithelium

EPIDEMIOLOGY

  • Develops in...

DIAGNOSIS

Leukoplakia is an asymptomatic white patch on the oral mucosa. 

HISTORY

  • Usually asymptomatic

  • History of tobacco or alcohol use or oral exposure to irritants

PHYSICAL EXAM

  • Location

    • 50% on tongue, m...

TREATMENT

  • All oral leukoplakias should be treated because they are potentially malignant.

  • Treatment may include the following:

    • For 2 to 3 circumscribed lesions, surgical excision is treatment of choice ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Regular, close follow-up, even after successful treatment

  • Biopsy as needed

DIET

Regular 

PATIENT EDUCATION

  • If biopsy is negative, stress importance o...

REFERENCES

1
Nadeau C, Kerr A. Evaluation and management of oral potentially malignant disorders. Dent Clin North Am.  2018;62(1):1–27. [View Abstract on OvidMedline]
2
Villa A, Woo S. Leukoplakia—a...

ADDITIONAL READING

  • Messadi DV. Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci.  2013;5(2):59–65. [View Abstract on OvidMedline]

  • Nair DR, Pruthy R, Pawar U, et al. Or...

CODES

ICD10

  • K13.21 Leukoplakia of oral mucosa, including tongue

  • K13.3 Hairy leukoplakia

ICD9

528.6 Leukoplakia of oral mucosa, including tongue 

SNOMED

  • 414603003 Leukoplakia of oral mucosa

  • 414952002 oral hai...

CLINICAL PEARLS

  • Excisional biopsy is indicated for any undiagnosed leukoplakia.

  • After treatment, up to 30% of leukoplakia recurs, and some leukoplakia still transforms to squamous cell carcinoma; thus,...

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