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Leukoplakia, Oral

Kathya Chartre, MD and Robert Ander, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Oral leukoplakia is a white plaque or patches on the oral mucosa, generally precancerous.

  • System(s) affected: gastrointestinal

  • Hyperplasia of squamous epithelium

EPIDEMIOLOGY

  • Develops in...

DIAGNOSIS

Leukoplakia is an asymptomatic white patch on the oral mucosa. 

HISTORY

  • Usually asymptomatic

  • History of tobacco or alcohol use or oral exposure to irritants

PHYSICAL EXAM

  • Location

    • 50% on tongue,...

TREATMENT

  • All oral leukoplakias should be treated.

  • Treatment may include the following:

    • For 2 to 3 circumscribed lesions, surgical excision

    • For multiple or large lesions where surgery would cause unacc...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • Regular, close follow-up, even after successful treatment

  • Biopsy as needed

DIET

Regular 

PATIENT EDUCATION

  • If biopsy is negative, stress importance o...

REFERENCES

1
Villa A, Woo S. Leukoplakia— a diagnostic and management algorithm. J Oral Maxillofac Surg.  2017;75(4):723–734. [View Abstract on OvidMedline]
2
Fuller C, Camilon R, Nguyen S, et al. ...

ADDITIONAL READING

  • Messadi DV. Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci.  2013;5(2):59–65. [View Abstract on OvidMedline]

  • Nair DR, Pruthy R, Pawar U, et al. O...

SEE ALSO

HIV/AIDS; Infectious Mononucleosis, Epstein-Barr Virus Infections 

CODES

ICD10

  • K13.21 Leukoplakia of oral mucosa, including tongue

  • K13.3 Hairy leukoplakia

ICD9

528.6 Leukoplakia of oral mucosa, including tongue 

SNOMED

  • 414603003 Leukoplakia of oral mucosa

  • 414952002 oral hai...

CLINICAL PEARLS

  • Excisional biopsy is indicated for any undiagnosed leukoplakia.

  • After treatment, up to 30% of leukoplakia recurs, and some leukoplakia still transforms to squamous cell carcinoma; thus,...

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