Liddle Syndrome (Pseudoaldosteronism)

Autosomal dominant (AD) disorder characterized by early-onset hypertension associated with hypokalemia, metabolic alkalosis, suppressed plasma renin activity, and aldosterone levels

M...

Family history of early-onset hypertension and/or hypokalemia

Moderate to severe hypertension presenting by age 10 to 30 years

Suboptimal response to conventional antihypertensives

Healthy diet (3)[A]

Regular exercise (3)[A]

Salt-restricted diet (4)

Diastolic BP (DBP) goal is <90 mm Hg for ages 30 to 59 years (3)[A]; for ages 18 to 29 years (3)[C].

BP go...

Patient with Liddle syndrome presents with early-onset and difficult-to-control hypertension with conventional treatment, positive family history of hypertension in the young (not nece...