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Liddle Syndrome (Pseudoaldosteronism)

Mony Fraer, MD, FACP, FASN and Kantima Phisitkul, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Autosomal dominant (AD) disorder characterized by early-onset hypertension associated with hypokalemia, metabolic alkalosis, suppressed plasma renin activity, and aldosterone levels

  • M...

DIAGNOSIS

HISTORY

  • Family history of early-onset hypertension and/or hypokalemia

  • Moderate to severe hypertension presenting by age 10 to 30 years

  • Suboptimal response to conventional antihypertensives

PHYSICAL EXAM

TREATMENT

GENERAL MEASURES

  • Healthy diet (3)[A]

  • Regular exercise (3)[A]

  • Salt-restricted diet (4)[B]

  • Diastolic BP (DBP) goal is <90 mm Hg for ages 30 to 59 years (3)[A]; for ages 18 to 29 years (3)[C]

  • BP ...

ONGOING CARE

PROGNOSIS

Overall good prognosis if hypertension is adequately controlled 

COMPLICATIONS

  • Complications stem from uncontrolled hypertension.

  • Significant end-organ damage can occur in uncontrol...

REFERENCES

1
Sahay M, Sahay RK. Low renin hypertension. Indian J Endocrinol Metab.  2012;16(5):728–739. [View Abstract on OvidMedline]
2
Garovic VD, Hilliard AA, Turner ST. Monogenic forms of low-re...

ADDITIONAL READING

Online Mendelian Inheritance of Man. Liddle syndrome. http://omim.org/entry/177200. Accessed February 26, 2018. http://omim.org/entry/177200. Accessed February 26, 2018. ??[View Abs...

CODES

ICD10

E26.89 Other hyperaldosteronism 

ICD9

255.14 Other secondary aldosteronism 

SNOMED

707747007 Pseudoprimary hyperaldosteronism (disorder) 

CLINICAL PEARLS

  • Patient with Liddle syndrome presents with early-onset and difficult-to-control hypertension with conventional treatment, positive family history of hypertension in the young (not nece...

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