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Liddle Syndrome (Pseudoaldosteronism)

Elise Joyce Barney, DO Reviewed 05/2023
 


BASICS

DESCRIPTION

  • Autosomal dominant (AD) disorder characterized by early-onset salt-sensitive hypertension associated with hypokalemia, metabolic alkalosis, suppressed plasma renin activity and aldos...

DIAGNOSIS

HISTORY

  • Family history of early-onset hypertension and/or hypokalemia

  • Moderate to severe hypertension presenting by age 10 to 30 years

  • Suboptimal response to conventional antihypertensives

PHYSICAL EXAM

TREATMENT

GENERAL MEASURES

  • Regular exercise

  • Salt-restricted diet (5)[B]

  • Moderate alcohol intake (6)[B]

  • BP goal is <130/80 mm Hg in most adults (6)[C].

  • Early diagnosis is key in prevention of long-ter...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Nephrology 

Patient Monitoring

Monitor blood pressure and electrolytes regularly. 

DIET

2-gram sodium restriction and enhanced intake of potassium 

PATIENT EDUCATION

P...

REFERENCES

1
Tetti M, Monticone S, Burrello J, et al. Liddle Syndrome: Review of the Literature and Description of a New Case. Int J Mol Sci. 2018;19(3):812. 
2
Planès C, Caughey GH. Regulation of the ep...

ADDITIONAL READING

Online Mendelian Inheritance of Man. Liddle syndrome. http://omim.org/entry/177200. Accessed February 26, 2018. http://omim.org/entry/177200. Accessed February ...

CODES

ICD10

E26.89 Other hyperaldosteronism 

SNOMED

707747007 Pseudoprimary hyperaldosteronism (disorder) 

CLINICAL PEARLS

  • Patient with Liddle syndrome presents with early-onset and resistant hypertension with conventional treatment, positive family history of hypertension in the young (not necessary), hyp...

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