Autosomal dominant (AD) disorder characterized by early-onset hypertension associated with hypokalemia, metabolic alkalosis, suppressed plasma renin activity, and aldosterone levels
Family history of early-onset hypertension and/or hypokalemia
Moderate to severe hypertension presenting by age 10 to 30 years
Suboptimal response to conventional antihypertensives
Healthy diet (3)[A]
Regular exercise (3)[A]
Salt-restricted diet (4)[B]
Diastolic BP (DBP) goal is <90 mm Hg for ages 30 to 59 years (3)[A]; for ages 18 to 29 years (3)[C]
Complications stem from uncontrolled hypertension.
Significant end-organ damage can occur in uncontrol...
Patient with Liddle syndrome presents with early-onset and difficult-to-control hypertension with conventional treatment, positive family history of hypertension in the young (not nece...
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