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Linear Immunoglobulin A Dermatosis

Tin Ming Timothy Mok, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Linear immunoglobulin A (IgA) dermatosis is a chronic autoimmune blistering skin disease that affects both adult and pediatric populations (1).

  • Both adult and pediatric forms are char...

DIAGNOSIS

HISTORY

  • Idiopathic forms of linear IgA dermatosis usually have a prodrome of pruritus or burning that occurs weeks prior to onset of blisters (bullae). Hives or urticaria may precede bullae. ...

TREATMENT

Given the paucity of linear IgA dermatosis, no large, randomized controlled trials have evaluated treatment. 

GENERAL MEASURES

Usually, drug-induced adult linear IgA disease is self-limited an...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Regular follow-up should be scheduled to assess for improvement, drug response, and necessary tailoring of therapy. 

PATIENT EDUCATION

  • Patients should be educated a...

REFERENCES

1
Patrício P, Ferreira C, Gomes MM, et al. Autoimmune bullous dermatoses: a review. Ann N Y Acad Sci.  2009;1173:203–210. [View Abstract on OvidMedline]
2
Kharfi M, Khaled A, Karaa A, et ...

ADDITIONAL READING

  • Adler NR, McLean CA, Aung AK, et al. Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overl...

CODES

ICD10

L13.8 Other specified bullous disorders 

ICD9

694.8 Other specified bullous dermatoses 

SNOMED

  • 95330001 Linear IgA dermatosis (disorder)

  • 238942002 Adult linear immunoglobulin A disease (disorder...

CLINICAL PEARLS

  • Linear IgA dermatosis is an autoimmune blistering disorder with a bimodal age distribution involving children <5 years and adults >60 years.

  • Idiopathic or medication-induced etiol...

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