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Lupus Erythematosus, Systemic (SLE)

Sahil Mullick, FAAFP, MD and Farzad Effan, MBBS Reviewed 04/2024
 


BASICS

DESCRIPTION

  • Multisystem autoimmune inflammatory disorder with variable presentation, disease course, and prognosis

  • Can manifest in any organ system, especially dermatologic, renal, hematologic, m...

DIAGNOSIS

  • Suspect in multisystem disease including fever, fatigue, and signs of inflammation

  • Classification criteria from European League Against Rheumatism/American College of Rheumatology (EULAR/ACR)...

TREATMENT

GENERAL MEASURES

  • Requires a multidisciplinary, individualized approach to treatment

  • General treatment goals: achieving remission or low disease activity, preventing flares and end-organ damage...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Intensity of monitoring depends on manifestations, severity, medication regimen, comorbidities

  • Stable, inactive disease without significant organ...

REFERENCES

1
Ameer MA, Chaudhry H, Mushtaq J, et al. An Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis, Classification, and Management. Cureus. 2022;14(10):e30330. doi: 10.7759/cureus.3033...

SEE ALSO

Antiphospholipid Antibody Syndrome 

CODES

ICD10

  • M32.0 Drug-induced systemic lupus erythematosus

  • M32.14 Glomerular disease in systemic lupus erythematosus

  • M32.19 Other organ or system involvement in systemic lupus erythematosus

  • M32.8 Other f...

CLINICAL PEARLS

  • Multisystem disease, variable presentation—maintain high index of suspicion for diagnosis

  • Increased all-cause mortality, particularly with renal disease, infections, cardiovascular dise...

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