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Lupus Erythematosus, Systemic (SLE)

Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Multisystem autoimmune inflammatory disorder with variable presentation, disease course, and prognosis

  • May manifest in any organ system, especially dermatologic, renal, hematologic, m...

DIAGNOSIS

  • Suspect in multisystem disease including fever, fatigue, and signs of inflammation

  • New classification criteria from European League Against Rheumatism (EULAR) and ACR in 2019: sensitivity 96%...

TREATMENT

GENERAL MEASURES

  • Requires a multidisciplinary, individualized approach to treatment

  • General treatment goals: achieving remission or low disease activity, preventing flares and end-organ damage...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Intensity of monitoring depends on specific manifestations, disease severity, medication regimen, and comorbidities

  • Stable, inactive disease with...

REFERENCES

1
Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritis Rheum...

ADDITIONAL READING

SEE ALSO

  • Buckley L, Guyatt G, Fink HA, et al. 2017 American College of Theumatology guideline for the prevention and treatment of clucocorticoid-induced osteoporosis. A...

SEE ALSO

Antiphospholipid Syndrome 

CODES

ICD10

  • M32.0 Drug-induced systemic lupus erythematosus

  • M32.14 Glomerular disease in systemic lupus erythematosus

  • M32.19 Other organ or system involvement in systemic lupus erythematosus

  • M32.8 Other f...

CLINICAL PEARLS

  • Multisystem disease with variable presentation—must maintain high index of suspicion for diagnosis

  • Increased all-cause mortality, particularly related to renal disease, infections, and ...

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