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Lymphoma, Burkitt

Daniel Callaway, MD, MPH and Jennifer Greene Welch, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Burkitt lymphoma is a mature B-cell neoplasm arising from lymph node germinal centers.

  • Highly aggressive, rapidly growing malignancy

  • Can present as lymphoma or leukemia

  • Three distinct f...

DIAGNOSIS

HISTORY

  • Rapidly progressive bulky adenopathy or extranodal mass

  • Symptoms of bone marrow involvement

    • Fatigue, exercise intolerance, bruising, epistaxis, other bleeding, fever

  • Abdominal presentati...

TREATMENT

If available, all patients should be offered participation in an appropriate clinical trial. 

MEDICATION

First Line

  • Intensive, short-term, multiagent chemotherapy administered in cycles (1)[A]

    • C...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Close monitoring of serum chemistries is critical due to high risk of tumor lysis syndrome and uric acid nephropathy.

  • CBC, liver function, and re...

REFERENCES

1
Okebe JU, Skoetz N, Meremikwu MM, et al. Therapeutic interventions for Burkitt lymphoma in children. Cochrane Database Syst Rev.  2011;(7):CD005198. [View Abstract on OvidMedline]
2
Pri...

CODES

ICD10

  • C83.70 Burkitt lymphoma, unspecified site

  • C83.71 Burkitt lymphoma, lymph nodes of head, face, and neck

  • C83.73 Burkitt lymphoma, intra-abdominal lymph nodes

  • C83.79 Burkitt lymphoma, extranodal ...

CLINICAL PEARLS

  • Burkitt lymphoma is an aggressive, mature B-cell malignancy most commonly diagnosed in childhood.

  • Burkitt lymphoma is strongly associated with t(8;14) and with EBV and malaria infection...

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