Burkitt lymphoma is a mature B-cell non-Hodgkin lymphoma (NHL) arising from lymph node germinal centers.
Highly aggressive, rapidly growing malignancy
Three distinct forms differing in...
Rapidly progressive bulky adenopathy or extranodal mass
Symptoms of bone marrow involvement
Fatigue, exercise intolerance, bruising, epistaxis, other bleeding, fever
Abdominal presentati...
Intensive, short-term, multiagent chemotherapy administered in cycles (1)[A]
...
Close monitoring of serum chemistries is critical due to high risk of tumor lysis syndrome and uric acid nephropathy.
CBC, liver function, and re...
C83.70 Burkitt lymphoma, unspecified site
C83.71 Burkitt lymphoma, lymph nodes of head, face, and neck
C83.73 Burkitt lymphoma, intra-abdominal lymph nodes
C83.79 Burkitt lymphoma, extranodal ...
Burkitt lymphoma is an aggressive, mature B-cell malignancy most commonly diagnosed in childhood.
Burkitt lymphoma is strongly associated with t(8;14) and with EBV and malaria infection...
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<bold>FIGURE 20-57. Burkitt lymphoma. A.</bold> A tumor of the jaw distorts the child's face. <bold>B.</bold> Lymph node is effaced by neoplastic lymphocytes with several starry sky macrophages (<i>arrows</i>).
<bold>FIGURE 20-57. Burkitt lymphoma. A.</bold> A tumor of the jaw distorts the child's face. <bold>B.</bold> Lymp...
Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates within the salivary glands or pharyngeal epithelium, and is shed into the saliva and respiratory secretions. In some people, the virus transforms pharyngeal epithelial cells, leading to nasopharyngeal carcinoma. In people who are not immune from childhood exposure, EBV causes infectious mononucleosis. EBV infects B lymphocytes, which undergo polyclonal act...
Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates w...
Burkitt Lymphoma (L3) White cells Increased, decreased or normal Red cells Normocytic, normochromic anemia Platelets Thrombocytopenia often present and severe Cytochemistry Sudan back B, peroxidase, specific esterase and nonspecific esterases negative Periodic acid Schiff negative TdT negative Oil red O positive HLA DR positive Immunophenotype CD19, CD20 and sIg positive Bone Marrow Smear PAS Stain
Burkitt Lymphoma (L3) White cells Increased, decreased or normal Red cells Normocytic, normochromic anemia Platelets Thrombo...