Diagnosis is by identification of malignant mast cells by their morphology, immunophenotype, and/or molecular signature. WHO defined these criteria in 2001 and updated in 2008.
To diagnose SM...
Avoid environmental triggers of mast cell degranulation (hymenoptera venom, extreme heat or temperat...
Depends on type of SM, coexisting disorders, severity of mediator-related symptoms, and therapy
Most children with ISM will continue to have ISM throughout their l...
Q82.2 Mastocytosis
D47.0 Histiocytic and mast cell tumors of uncertain behavior
C96.2 Malignant mast cell tumor
757.33 Congenital pigmentary anomalies of skin
202.60 Malignant mast cell tum...
Symptoms of mast cell activation can overshadow the cutaneous findings, which can be subtle and easily overlooked. The brownish papules and macules should be carefully sought in cases ...
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