Multiple Endocrine Neoplasia (MEN) Syndromes

Anup Sabharwal, MD MBA FACC FACE FASPC FNLA FEAA Reviewed 05/2023

BASICS

Multiple endocrine neoplasia (MEN) syndromes are autosomal dominant disorders that predispose individuals to the development of neoplasms, usually benign but sometimes malignant, in characteris...

DIAGNOSIS

MEN1: Clinical diagnosis of sporadic MEN1 is made in patients with tumors in two of the three main MEN1-associated endocrine glands; familial MEN1 is diagnosed in individuals who have one of...

TREATMENT

In general, treatment recommendations align with those of the specific isolated tumor.

ISSUES FOR REFERRAL

If diagnosis remains in question, a referral to an endocrine center of excellence ma...

ONGOING CARE

DIET

Calcium and vitamin D should be limited in patients with hypercalcemia secondary to hyperparathyroidism until surgical intervention is complete. Patients with gastrinoma should avoid ...

REFERENCES

Falchetti A. Genetics of multiple endocrine neoplasia type 1 syndrome: what’s new and what’s old. F1000Res. 2017;6:F1000 Faculty Rev-73. [View Abstract on Ov...

CODES

ICD10

E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
E31.21 Multiple endocrine neoplasia [MEN] type I
E31.22 Multiple endocrine neoplasia [MEN] type IIA
E31.23 Multiple endocrine ne...

CLINICAL PEARLS

Young people (<30 years of age) with hypercalcemia: Think MEN1.
Multiglandular involvement in hyperparathyroidism: Think MEN1.
Adrenal mass and tachycardia: Think pheochromocytoma.
A p...

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