Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells.
This clonal proliferation in the bone marrow (BM) can cause extensive skeletal destruction with osteolytic l...
34% of patients are asymptomatic at the time of presentation.
Hypercalcemia (28%): anorexia, nausea, somnolence, and polydipsia
Elevated creatinine (48%)
Anemia (73%)
Bony lesions (80%): ...
Treatment varies depending on level of disease activity and stage of MM.
Key determinant factor in choosing chemotherapy regimen is to establish if the patient is an autologous stem cell tran...
http://myeloma.org/Main.action
http://www.nccn.org/patients/guidelines/myeloma/index.html
Median survival overall is 3 years. The 5-year survival rate is around 35...
Grass S, Preuss KD, Thome S, et al. Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in fa...
C90.00 Multiple myeloma not having achieved remission
C90.01 Multiple myeloma in remission
C90.02 Multiple myeloma in relapse
203.00 Multiple myeloma, without mention of having achieved re...
MM is a plasma cell malignancy that causes end-organ damage.
Look for presence of “CRAB” (hypercalcemia, renal insufficiency, anemia, and bone lesions).
Suspect MM if high total protein-...
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