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Multiple Sclerosis

Afsha Rais Kaisani, MD, FAAFP and Niyomi De Silva, MD Reviewed 05/2023
 


BASICS

An autoimmune disease directed against components of the neural myelin sheath causing demyelination, leading to progressive axonal loss and CNS atrophy affecting primarily white matter but may ...

DIAGNOSIS

A person with MS can present with a number of neurologic signs and symptoms depending on the locations of the lesion. The essential means of diagnoses is to demonstrate evidence of CNS lesio...

TREATMENT

GENERAL MEASURES

  • Multidisciplinary team approach is paramount, including physical, occupational and speech therapy, mental health specialist, pharmacists, urologist, neurologist, and dietitia...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Assessing the severity of neurologic impairment from MS can be done using the Kurtzke Expanded Disability Status Scale (EDSS): The EDSS quantifi...

REFERENCES

1
Saguil A, Farnell Iv EA, Jordan TS. Multiple Sclerosis: A Primary Care Perspective. Am Fam Physician. 2022;106(2):173-183. 
2
Raffel  J, Wakerley  B, Nicholas  R. Mul...

CODES

ICD10

G35 Multiple sclerosis 

SNOMED

  • 24700007 Multiple sclerosis (disorder)

  • 428700003 Primary progressive multiple sclerosis

  • 425500002 secondary progressive multiple sclerosis (disorder)

  • 426373005 rel...

CLINICAL PEARLS

  • MS: an immune-mediated inflammatory disease causing demyelination, neuronal loss, and scarring within the CNS.

  • Most common cause of nontraumatic neurologic disability in young adults.

  • Di...

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