Myasthenia Gravis

Melody Jordahl-Iafrato, MPH, MD and Jennifer R Collins, PharmD Reviewed 05/2023

BASICS

DESCRIPTION

A disorder of neuromuscular transmission characterized by fluctuating muscle weakness:

Ocular myasthenia gravis (MG) (15%): weakness limited to eyelids and extraocular muscles
General...

DIAGNOSIS

Myasthenia Gravis Foundation of America Clinical Classification :

Class I: any eye muscle weakness, possible ptosis, no other evidence of muscle weakness elsewhere
Class II: eye muscle weakne...

TREATMENT

GENERAL MEASURES

Three basic approaches: symptomatic, immunosuppressive, and supportive. Most should receive symptomatic treatment along with immunosuppressive and/or supportive modalities

MEDICATION

ONGOING CARE

PATIENT EDUCATION

Myasthenia Gravis Foundation of America (MGFA): http://www.myasthenia.org/

PROGNOSIS

Overall good but highly variable
Myasthenic crisis associated with substantial morbidit...

REFERENCES

Berrih-Aknin S, Frenkian-Cuvelier M, Eymard B. Diagnostic and clinical classification of autoimmune myasthenia gravis. J Autoimmun. 2014;48–49:143–148. [Vi...

ADDITIONAL READING

Menon D, Barnett C, Bril V. Novel treatments in myasthenia gravis. Front Neurol. 2020;11(538)1-12.

CODES

ICD10

G70.01 Myasthenia gravis with (acute) exacerbation
G70.00 Myasthenia gravis without (acute) exacerbation
G70.0 Myasthenia gravis
G70 Myasthenia gravis and other myoneural disorders

SNOMED

230684...

CLINICAL PEARLS

An autoimmune disease, marked by abnormal fatigability and weakness of selected muscles, which is relieved by rest
> 50% of patients present with ocular symptoms (ptosis and/or diplo...

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