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Myasthenia Gravis

Melody A. Jordahl-Iafrato, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

Primary disorder of neuromuscular transmission characterized by fluctuating muscle weakness: 
  • Ocular myasthenia gravis (MG) (15%): weakness limited to eyelids and extraocular muscles

  • G...

DIAGNOSIS

Myasthenia Gravis Foundation of America Clinical Classification (2)[C]: 
  • Class I: any eye muscle weakness, possible ptosis, no other evidence of muscle weakness elsewhere

  • Class II: eye muscle ...

TREATMENT

GENERAL MEASURES

  • Treatment based on age, gender, and disease severity and progression

  • Three basic approaches: symptomatic, immunosuppressive, and supportive. Few should receive a single therap...

ONGOING CARE

PATIENT EDUCATION

MG Foundation of America (MGFA): http://www.myasthenia.org/ 

PROGNOSIS

  • Overall good but highly variable

  • Myasthenic crisis associated with substantial morbidity and 4% mortal...

REFERENCES

1
Berrih-Aknin S, Frenkian-Cuvelier M, Eymard B. Diagnostic and clinical classification of autoimmune myasthenia gravis. J Autoimmun.  2014;48–49:143–148. [View Abstract on OvidMedline...

ADDITIONAL READING

  • Angelini C. Diagnosis and management of autoimmune myasthenia gravis. Clin Drug Investig.  2011;31(1):1–14. [View Abstract on OvidMedline]

  • Meriggioli MN. Myasthenia gravis: imm...

CODES

ICD10

  • G70.00 Myasthenia gravis without (acute) exacerbation

  • G70.01 Myasthenia gravis with (acute) exacerbation

  • P94.0 Transient neonatal myasthenia gravis

ICD9

  • 358.00 Myasthenia gravis without (acute)...

CLINICAL PEARLS

  • An autoimmune disease, marked by abnormal fatigability and weakness of selected muscles, which is relieved by rest

  • Anticholinesterase medication and a thymectomy lessen symptom severity...

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