Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders that share a common cell of origin in the pluripotent hematopoietic stem cell.

This topic focuses on chronic myelog...

Constitutional symptoms are common, though a minority are asymptomatic.

All MPNs may share the following symptoms (3): 

• Constitutional: fatigue, weakness, night swea...

PV:

• Phlebotomy is first line for PV, with goal hema...

Avoid situations increasing their risk of thrombosis, such as prolonged immobility.

With splenomegaly, patients may be advised to avoid high-contact sports and other activ...

D47.1 Chronic myeloproliferative disease

C92.10 Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission

D45 Polycythemia vera

D47.3 Essential (hemorrhagic) thrombocythemia

C93...

MPNs result from mutations that activate hematopoiesis, resulting in proliferation of cells of myeloid, erythroid, and/or megakaryocyte lineages.

CML is characterized by granulocytosis,...