Myeloproliferative neoplasms (MPNs) are a group of clonal disorders that share a common cell of origin in the pluripotent hematopoietic stem cell.
MPNs are characterized by proliferat...
Many MPN cases are found incidentally on routine blood work.
CML: 20–50% of patients are asymptomatic at time of diagnosis.
Fatigue, malaise, weight loss, excessive perspiration, abdomi...
CML: TKIs are mainstay of treatment.
Chronic phase: imatinib mesylate (Gleevec): 400 mg/day is the safest choice.
Other optio...
CML: 10-year survival rate ~80% from time of diagnosis; 85% will die in blast crisis; 12- to 18-month median survival for accelerated phase; 3- to 6-month median survival for bla...
D47.1 Chronic myeloproliferative disease
C92.10 Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
D45 Polycythemia vera
D47.3 Essential (hemorrhagic) thrombocythemia
C93...
MPNs are a group of clonal disorders that share a common cell of origin in the pluripotent hematopoietic stem cell.
MPNs are characterized by proliferation of cells of myeloid lineage—g...
Sign up for a 10-day FREE Trial now and receive full access to all content.