Myeloproliferative neoplasms (MPNs) are a group of clonal disorders that share a common cell of origin in the pluripotent hematopoietic stem cell.
MPNs are characterized by proliferat...
Many MPN cases are found incidentally on routine blood work.
CML: Most patients are asymptomatic at time of diagnosis.
Fatigue, malaise, weight loss, excessive perspiration, abdominal...
CML
Chronic phase: imatinib mesylate (Gleevec): 400 mg/day, a TKI. Dasatinib and nilotinib are also approved for use in th...
CML: 10-year survival rate ~80% from time of diagnosis; 85% will die in blast crisis; 12- to 18-month median survival for accelerated phase; 3- to 6-month median survival for bla...
Cervantes F, Dupriez B, Pereira A, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and ...
D47.1 Chronic myeloproliferative disease
C92.10 Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission
D45 Polycythemia vera
D47.3 Essential (hemorrhagic) thrombocythemia
C93...
MPNs are a group of clonal disorders that share a common cell of origin in the pluripotent hematopoietic stem cell.
MPNs are characterized by proliferation of cells of myeloid lineage—g...
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