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Myeloproliferative Neoplasms

Justin T Ertle, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders that all originate in the pluripotent hematopoietic stem cell. This topic focuses on chronic myelogenous leukemia ...

DIAGNOSIS

HISTORY

Constitutional symptoms are common, though a significant minority are asymptomatic. 
  • Any MPN may have these symptoms (1): 

    • Constitutional: fatigue, weakness, night sweats,...

TREATMENT

GENERAL MEASURES

  • PV:

    • Phlebotomy is first line; goal hematocrit <45% in men and <42% in women (1)[A].

      • Achieving goal hematocrit decreases mortality from cardio...

ONGOING CARE

PATIENT EDUCATION

  • Avoid situations increasing risk of thrombosis.

  • With splenomegaly, patients are advised to avoid activities increasing risk of rupture.

PROGNOSIS

  • CML prognosis is strongly t...

REFERENCES

1
Patel AB, et al. New Strategies in Myeloproliferative Neoplasms: The Evolving Genetic and Therapeutic Landscape. Clin Cancer Res. 2016;22(5):1037-47.

ADDITIONAL READING

SEE ALSO

Leukemia, Chronic Myelogenous; Polycythemia Vera 

CODES

ICD10

  • D47.1 Chronic myeloproliferative disease

  • C92.10 Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission

  • D45 Polycythemia vera

  • D47.3 Essential (hemorrhagic) thrombocythemia

  • C93...

CLINICAL PEARLS

  • MPNs result from mutations that activate hematopoiesis, resulting in proliferation of cells of myeloid, erythroid, and/or megakaryocyte lineages.

  • CML is characterized by granulocytosis,...

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