Uric acid requires the enzyme uricase to convert it to a more soluble compound (allantoin); in humans, the enzyme is absent making the kidney more susceptible to the side effects of uric acid c...
Hyperuricemic acute renal failure
Hyperkalemia: weakness, paresthesias, muscle cramps, nausea, vomiting, diarrhea, anorexia
Hyperphosphatemia: acute nephrocalcinosis
Hypocalcemia: muscle cramps...
Hyperuricemic acute renal failure: Prevent by pretreating with allopurinol or rasburicase and hydrating patient prior to administration of chemotherapeutic agents for leukemia or l...
Moderation of purine intake
For nephrolithiasis, fluid intake to produce urine output of >2 L/day unless limited by acute or chronic renal failure
In renal failure, restrict sodium f...
Gibson T. Hyperuricemia, gout and the kidney. Curr Opin Rheumatol. 2012;24(2):127–131.
Johnson RJ, Nakagawa T, Jalal D, et al. Uric acid and chronic kidney disease: which is ch...
N28.89 Other specified disorders of kidney and ureter
N20.0 Calculus of kidney
M10.30 Gout due to renal impairment, unspecified site
274.10 Gouty nephropathy, unspecified
274.11 Uric acid n...
Uric acid is water-insoluble in the acidic environment of the distal nephron of the kidney.
Due to the lack of the enzyme uricase, which converts uric acid into a more soluble compound,...
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