Nesidioblastosis (NB) is a disease characterized by hyperfunctioning pancreatic β cells, usually associated with hypoglycemia in the presence of high endogenous insulin levels. It is...
Infants/children: irritability, lethargy, convulsions, coma, hunger, mental retardation
Adults: lethargy, confusion, sweating, chills, palpitations, dizziness, loss of consciousness, s...
Diazoxide: blocks receptors on pancreatic β cells, keeping the K channel op...
Endocrinology
Nutrition
Surgery (if patient failed conservative therapy)
Genetics
For infants and children, watch for signs of neurohypoglycemia bec...
42681006 Islet cell hyperplasia (disorder)
66149005 Hyperplasia of pancreatic islet beta cell (disorder)
NB is a genetically linked disorder, typically seen in infancy. However, there has been an association with gastric bypass surgery.
Insulinoma symptoms generally occur in the fasting st...
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