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Neuroblastoma

Shanzay Haider, MD, Syed Jaan Naqvi, MD and Anna Freitag, MD, FACP, FACE, MACDS Reviewed 06/2019
 


BASICS

Neuroblastoma is usually exclusively a disease of children and is an umbrella term that is used to refer to a spectrum of neuroblastic tumors that arise from embryonic sympathetic ganglion cell...

DIAGNOSIS

HISTORY

  • Constitutional symptoms (fever, malaise, loss of appetite)

  • Depending on the primary location of tumor and whether or not there is metastasis, following symptoms may or may not be prese...

TREATMENT

GENERAL MEASURES

  • Children’s Oncology Group risk stratification (1)[A]: Patients are stratified to low, intermediate, and high risk based on INSS stage, age, INPC histology classification, N-m...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • For low-risk patients stratified to observation, follow up with ultrasound. An enlarging neoplasm necessitates operative intervention.

  • Follow-up ...

REFERENCES

1
American Cancer Society. Neuroblastoma—key statistics about neuroblastoma. https://www.cancer.org/cancer/neuroblastoma/about/key-statistics.html. Accessed October 1, 2018. https://www.canc...

ADDITIONAL READING

Craddock JA, Quinones RR, Keating AK, et al. Neoplastic Disease. In: Hay WWJr, Levin MJ, Deterding RR, et al, eds. Current Diagnosis & Treatment: Pediatrics. 24th ed. New York,...

CODES

ICD10

  • C74.90 Malignant neoplasm of unsp part of unspecified adrenal gland

  • C48.0 Malignant neoplasm of retroperitoneum

  • C38.3 Malignant neoplasm of mediastinum, part unspecified

  • C76.3 Malignant neopla...

CLINICAL PEARLS

  • Symptoms are variable and reflect tumor location.

  • Tumor behavior is highly variable; some regress spontaneously, whereas others are very aggressive with high mortality.

  • Treatment of neur...

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