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Neuropathy, Peripheral

Christine S. Persaud, MBA, MD and Terry SeeToe, MD Reviewed 06/2022
 


BASICS

DESCRIPTION

  • A functional or structural disorder of the peripheral nervous system (PNS), affecting any combination of motor, sensory, or autonomic nerves

  • Peripheral motor involvement causes muscle...

DIAGNOSIS

HISTORY

  • A detailed inquiry for symptoms of sensory, motor, or autonomic dysfunction:

    • Numbness, tingling, prickling, burning pain, a “tightly wrapped” sensation, and an “unsteady gait”

    • Distal we...

TREATMENT

GENERAL MEASURES

  • Counsel on foot care and properly fitted footwear.

  • Monitor feet for early signs of skin breakdown and injury.

  • Targeted treatment for underlying systemic conditions

MEDICATION

First Line

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Strengthening exercises improved muscle strength, which may assist in function.

  • Flu vaccination should be avoided in the 1st year following GBS.

DIET

Assess for B12 ...

REFERENCES

1
Hanewinckel R, Ikram MA, Van Doorn P A. Peripheral Neuropathies. Handb Clin Neurol. 2016;138:263-82.
2
Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease i...

CODES

ICD10

  • G62.9 Polyneuropathy, unspecified

  • G60.9 Hereditary and idiopathic neuropathy, unspecified

  • G60.8 Other hereditary and idiopathic neuropathies

  • G60.0 Hereditary motor and sensory neuropathy

  • G62.89...

CLINICAL PEARLS

  • Diagnosis is made by history and physical exam, targeted laboratory testing, NCS/EMG, skin biopsy, or ANS testing.

  • Consider hereditary neuropathy if patient has an early age of PN sympt...

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