Neuropathy, Peripheral

Christine S. Persaud, MBA, MD Reviewed 04/2024

BASICS

A disease of the peripheral nervous system that has multiple etiologies including diabetes, neurotoxic agents, alcohol use, nutrition deficiencies, immune-mediated causes, nerve compression, ne...

DIAGNOSIS

Diagnosis is made by a detailed patient history, clinical symptoms, laboratory tests and diagnostic testing of nerve conductions studies/ electromyography (NCS/ EMG) and possibly nerve biops...

TREATMENT

GENERAL MEASURES

Counsel on foot care and monitoring for signs of skin breakdown.
Targeted treatment for underlying systemic conditions

MEDICATION

First Line

Treatment of neuropathic pain: eviden...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Exercises to improve muscle strength.
Avoid flu vaccination the 1st year following GBS.

DIET

Assess for B12 deficiency, ingestion of heavy metal toxins, thiamine def...

REFERENCES

Zajączkowska R, Kocot-Kępska M, Leppert W, et al. Mechanisms of Chemotherapy-Induced Peripheral Neuropathy. Int J Mol Sci. 2019;20(6):1451. doi: 10.3390/ijms20061451. PMID: 30909387; PMCID...

CODES

ICD10

G62.9 Polyneuropathy, unspecified
G60.9 Hereditary and idiopathic neuropathy, unspecified
G60.8 Other hereditary and idiopathic neuropathies
G60.0 Hereditary motor and sensory neuropathy
G62.89...

CLINICAL PEARLS

Diagnosis is made by history and physical exam, targeted laboratory testing, NCS/EMG, skin biopsy, or ANS testing.
Consider hereditary neuropathy if patient has an early age of PN sympt...

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