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Neutropenia, Cyclic

Justin T Ertle, MD and Mark H Dalgetty, D.O. Reviewed 04/2024
 


BASICS

DESCRIPTION

Cyclic neutropenia is a rare nonmalignant primary hematologic disorder with periodic neutropenia, often associated with fever, malaise, and recurring infections, which typically pres...

DIAGNOSIS

HISTORY

  • Onset of cCyclic neutropenia can occur as early as a few months of age, and typically presents in the first few years of life, though presentation or recognition may occur later (1)[...

TREATMENT

MEDICATION

First Line

  • Granulocyte Colony Stimulating Factor (G-CSF) has been shown to increase neutrophil counts, decrease febrile episodes and infections, and improve survival (1)[B],(2)[C],...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Recommendations while on G-CSF treatment (3)[C]: 
  • CBC including ANC at least every 4 months

  • Biochemical parameters including hepatic and renal fu...

REFERENCES

1
Dale DC, Bolyard AA, Shannaon JA, et al. Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor. Blood Adv. 2022;6(13):3861-3869. doi: 10....

ADDITIONAL READING

SEE ALSO

  • Garratt LW. Current Understanding of the Neutrophil Transcriptome in Health and Disease. Cells. 2021;10(9):2406. doi: 10.3390/cells10092406. ...

CODES

ICD10

D70.4 Cyclic neutropenia 

SNOMED

191347008 Cyclical neutropenia (disorder) 

CLINICAL PEARLS

  • Cyclic Neutropenia is a rare non-malignant primary hematologic disorder characterized by periodic episodes of neutropenia, occurring on average every 3 weeks.

  • Typically, caused by a her...

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