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Neutropenia, Cyclic

Tisha Smith Boston, FAAFP, MD Reviewed 06/2022
 


BASICS

Rare condition of cycling periods of neutropenia that typically presents in the first year of life. (1

DESCRIPTION

  • A rare benign hematologic disorder characterized by recurrent fevers, malaise,...

DIAGNOSIS

HISTORY

  • Usually an infant (age <1 year)

  • Recurrent fevers, pharyngitis, gingivitis, stomatitis, and other bacterial infections

  • Familial pattern in some cases (autosomal dominant)

  • Symptoms can ...

TREATMENT

GENERAL MEASURES

  • Genetic counseling

  • Routine hospitalization not required; however, patients with unexplained fever and neutropenia should receive prompt evaluation and emperic treatment until ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Once the diagnosis is established and G-CSF treatment has started 
  • Blood counts should be obtained periodically to avoid overtreatment or undertr...

REFERENCES

1
Dale DC. Cyclic and chronic neutropenia: an update on diagnosis and treatment. Advances in Hematology. 2011; (11): 868-869.
2
Horwitz MS, Corey SJ, Grimes HL, Tidwell T. ELANE mutations in ...

CODES

ICD10

D70.4 Cyclic neutropenia 

SNOMED

191347008 Cyclical neutropenia (disorder) 

CLINICAL PEARLS

  • Cyclic neutropenia is a rare benign disease; bowel necrosis and perforation are rare but may be associated with mortality.

  • Diagnosis requires serial blood counts over six to eight weeks...

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