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Optic Atrophy

Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Definition: irreversible death of the axons that composes the optic nerve

  • Clinical manifestations: visual loss of variable degree, which can include loss of acuity (i.e., sharpness of...

DIAGNOSIS

HISTORY

  • Family history of visual loss

  • History of congenital or other neurologic disorders

  • History of known etiology for ONA

  • Painless loss of visual acuity

    • Bilateral; can be synchronous or metac...

TREATMENT

GENERAL MEASURES

  • Optic nerve damage may be reversible, so early detection and treatment of the underlying etiology is critical.

  • Correction of an underlying nutritional deficiency and discontin...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Determined by the associated cause

  • Progressive ONA may require more frequent follow-up and second- and third-line evaluation for etiologies of ONA.

Patient Monitoring

REFERENCES

1
Mascialino B, Leinonen M, Meier T. Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe. Eur J Ophthalmol.  2012;22(3):461–465. [View Abstrac...

CODES

ICD10

  • H47.20 Unspecified optic atrophy

  • H47.22 Hereditary optic atrophy

  • H47.219 Primary optic atrophy, unspecified eye

  • H47.299 Other optic atrophy, unspecified eye

  • H47.239 Glaucomatous optic atrophy, ...

CLINICAL PEARLS

  • ONA is an ophthalmoscopic sign and not an etiologic diagnosis. It is characterized by pale optic disc on funduscopic exam associated with clinical evidence for ONA.

  • Symptoms of ONA migh...

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