Focal disorder of hyperactive bone resorption followed by excessive bone formation (remodeling) that is stimulated by abnormal osteoclasts
Results in an enlarged, disorganized, weaken...
Frequently asymptomatic (70–90% of patients); often noted as incidental finding (2)[B]
Resting or nocturnal bone pain is the most common complaint
Secondary osteoarthritis
Hearing loss ...
Shoe orthoses to counteract limb shortening
Hearing aids for severe sensorineural deafness
Splints for severely resorbed areas with high risk of fracture (rarely)
Full activity to maintain function
Avoid excessive mechanical/repetitive stress on involved bones
Follow-up visits every 2 to 4 months during drug...
Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, et al. Epidemiology of Paget's disease of bone: a systematic review and meta-analysis of ...
M88.9 Osteitis deformans of unspecified bone
M88.88 Osteitis deformans of other bones
M88.1 Osteitis deformans of vertebrae
M88.0 Osteitis deformans of skull
M90.60 Osteitis deformans in neopla...
OD (Paget disease of bone) is often asymptomatic. When symptomatic, bone pain is the most common complaint.
Osteolysis and thickened bony cortices are common radiographic findings in OD...
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<bold>FIG. 122.5.</bold> A: Lateral radiograph of the skull shows the thickened skull and osteoporosis circumscripta of both lateral temporal bones (<italic>short arrows</bold>, right; <italic>long arrows</bold>, left). Platybasia is present. B: Axial section of the skull by computed tomography (CT) demonstrates cortical atrophy and a wide, thick skull mostly composed of wide diploic areas <italic>(arrows)</bold>.
<bold>FIG. 122.5.</bold> A: Lateral radiograph of the skull shows the thickened skull and osteoporosis circumscripta of both la...
Overgrowth of the vertebral body at L3 in this patient with Paget?s disease (compare with Figure 2-12)
Paget disease. (A) A radiograph of the leg shows marked involvement of the tibia by Paget disease with thickening and disorganization of the cortex. Note the normal appearance of the fibula. (B) The proximal end of a femur affected by Paget disease shows replacement of the normal cancellous architecture by coarse, thick bundles of trabecular bone. The cortical bone is irregularly thickened and exhibits a coarse, granular appearance instead of the normally smooth cortical bone. (C) A radiogr...
Paget disease. (A) A radiograph of the leg shows marked involvement of the tibia by Paget disease with thickening and disorganization of th...
Paget disease. (A) A section of bone shows prominent basophilic cement lines with several microfractures. (B) With this Goldner stain, two osteoclasts are evident, each containing many more nuclei than normal. There are numerous osteoblasts, together with new, unmineralized osteoid (red) and marrow fibrosis.
Paget disease. (A) A section of bone shows prominent basophilic cement lines with several microfractures. (B) With this Goldner stain, two ...