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Ovarian Cancer

Nidha Mattappally, MD and Susan L. Zweizig, MD Reviewed 06/2019
 


BASICS

There are >22,000 new cases of ovarian cancer annually in the United States, and approximately 14,000 women will die of their disease, making this the most lethal of gynecologic cancers. Thi...

DIAGNOSIS

HISTORY

  • Acute presentation:

    • Shortness of breath (pleural effusion)

    • Nausea, vomiting, decreased oral intake (bowel obstruction)

    • Calf pain, shortness of breath (venous thromboembolism)

    • Severe abdom...

TREATMENT

GENERAL MEASURES

  • Surgical exploration with staging and debulking is critical. Optimal cytoreduction of tumor burden enhances effectiveness of adjuvant therapy and is associated with longer su...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Physical exam every 3 months for the first 2 years after diagnosis, every 6 months until 5 years, and then annually thereafter

  • If CA-125 elevated...

REFERENCES

1
Beral V, Doll R, Hermon C, et al; and Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epi...

ADDITIONAL READING

  • Prat J; for FIGO Committee on Gynecologic Oncology. Staging classification for the cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet.  2014;124(1):1–5....

CODES

ICD10

  • C56.9 Malignant neoplasm of unspecified ovary

  • C56.1 Malignant neoplasm of right ovary

  • C56.2 Malignant neoplasm of left ovary

ICD9

183.0 Malignant neoplasm of ovary 

SNOMED

  • 93934004 Primary malign...

CLINICAL PEARLS

  • Family history of ovarian cancer or early-onset breast cancer is the most significant risk factor for the development of ovarian cancer, yet the vast majority of cases remain sporadic.

  • ...

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