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Paget Disease of the Breast

Anette Galang Gawelko, DO and Tracy O. Middleton, DO, FACOFP Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Rare disease of the nipple-areola complex (NAC) typically associated with underlying in situ or invasive carcinoma

  • Characterized by eczematous changes of the nipple, erythema, ulcerat...

DIAGNOSIS

HISTORY

  • Scaly, raw, vesicular, or ulcerated lesion that begins on the nipple and then spreads to the areola

  • Pain, burning, and pruritus may be present even before clinically evident disease.

  • Ni...

TREATMENT

MEDICATION

  • Systemic adjuvant chemotherapy and/or endocrine therapy is based on the stage and hormone receptor status of the associated cancer.

  • In Paget disease without an associated cancer or ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Oncology consultation 

Patient Monitoring

  • After successful treatment for Paget disease of the breast, patients should start an individualized cancer surveillance pr...

REFERENCES

1
Lim HS, Jeong SJ, Lee JS, et al. Paget disease of the breast: mammographic, US, and MR imaging findings with pathologic correlation. Radiographics.  2011;31(7):1973–1987. [View Abstra...

ADDITIONAL READING

CODES

ICD10

  • C50.019 Malignant neoplasm of nipple and areola, unsp female breast

  • C50.011 Malignant neoplasm of nipple and areola, right female breast

  • C50.012 Malignant neoplasm of nipple and areola, left ...

CLINICAL PEARLS

  • Any chronic or nonhealing nipple or breast lesions should be biopsied to rule out malignancy.

  • Further imaging is indicated to rule out additional underlying breast malignancy.

  • Breast mam...

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