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Pancreatic Cancer

Marcelle Meseeha, MD and Maximos Attia, MD, FAAFP Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Adenocarcinoma of the exocrine pancreas (90% of pancreatic cancers) is the fourth most common cause of cancer death in the United States and the ninth most common cancer in women.

  • Rar...

DIAGNOSIS

HISTORY

  • Depends on tumor location; majority become symptomatic late in disease. About 60–70% of pancreatic cancers develop in the pancreatic head and block the periampullary bile duct, causin...

TREATMENT

  • Surgical resection: only chance of cure; no role for pancreatic resection in metastatic disease. As few as 15–20% are candidates for resection.

  • Criteria for unresectability: extrapancreatic s...

ONGOING CARE

DIET

  • Anorexia, asthenia, pain, and depression may contribute to cachexia.

  • Fat malabsorption due to exocrine pancreatic insufficiency may contribute to malnutrition; pancreatic enzyme replac...

REFERENCES

1
Ducreux M, Cuhna AS, Caramella C, et al; for ESMO Guidelines Committee. Cancer of the pancreas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol.  2...

ADDITIONAL READING

  • Gurusamy KS, Kumar S, Davidson BR, et al. Resection versus other treatments for locally advanced pancreatic cancer. Cochrane Database Syst Rev.  2014;(2):CD010244. [View Abstra...

CODES

ICD10

  • C25.9 Malignant neoplasm of pancreas, unspecified

  • C25.0 Malignant neoplasm of head of pancreas

  • C25.1 Malignant neoplasm of body of pancreas

  • C25.2 Malignant neoplasm of tail of pancreas

  • C25.7 Ma...

CLINICAL PEARLS

  • Sudden onset of diabetes mellitus in nonobese adults aged >40 years may warrant consideration of pancreatic cancer in selected cases.

  • Presence of occult peritoneal tumor cells denote...

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