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Parvovirus B19 Infection

David L. Anderson, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Human parvovirus B19 is the primary cause of acute erythema infectiosum (EI, or fifth disease).

  • Individuals with increased RBC turnover (e.g., sickle cell anemia [SS]) are more suscep...

DIAGNOSIS

HISTORY

  • Rash

  • Headache

  • Pharyngitis

  • Coryza and rhinorrhea

  • Arthralgias and arthritis

  • Nausea and GI disturbances are more frequent and severe in adults (nonspecific flulike illness).

  • Pruritus (especial...

TREATMENT

GENERAL MEASURES

  • No therapy is usually needed (4)[C].

  • Cessation of immunosuppressive therapy allows some patients to clear chronic infections.

  • B19-associated anemia in HIV-positive patients may...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

Periodic blood counts for anemic patients 

PATIENT EDUCATION

REFERENCES

1
de Jong EP, de Haan TR, Kroes AC, et al. Parvovirus B19 infection in pregnancy. J Clin Virol.  2006;36(1):1–7. [View Abstract on OvidMedline]
2
Santonja C, Nieto-González G, Santos-Bri...

ADDITIONAL READING

  • Azevedo KM, Setúbal S, Camacho LA, et al. Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients. Mem Inst Oswaldo Cruz.  2012;107(3):356–3...

CODES

ICD10

  • B34.3 Parvovirus infection, unspecified

  • B08.3 Erythema infectiosum [fifth disease]

ICD9

  • 079.83 Parvovirus B19

  • 057.0 Erythema infectiosum (fifth disease)

SNOMED

  • 186748004 Parvovirus infection

  • 34730...

CLINICAL PEARLS

  • Parvovirus B19 infection is usually a benign, self-limited illness with no long-term effects.

  • The rash of EI, a “slapped cheek” appearance, signifies that the patient is no longer infec...

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