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Parvovirus B19 Infection

David S. Quimby, MD Reviewed 06/2020
 


BASICS

DESCRIPTION

  • Human parvovirus B19 is the cause of erythema infectiosum (fifth disease, morbus quintus)

  • Individuals with increased RBC turnover (sickle-cell anemia, spherocytosis, thalassemia) are ...

DIAGNOSIS

HISTORY

  • May have a prodrome of fever, coryza, pharyngitis, headache, rhinorrhea, nausea.

  • Rash and arthralgias develop after these symptoms.

  • Arthralgias may last for weeks or longer.

PHYSICAL EXAM

TREATMENT

GENERAL MEASURES

  • No therapy is usually needed (4)[C].

  • Cessation of immunosuppressive therapy allows some patients to clear chronic infections.

  • B19-associated anemia in HIV-positive patients may...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Periodic blood counts for anemic patients until they have reticulocyte recovery 

PATIENT EDUCATION

REFERENCES

1
Ornoy A, Ergaz Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res.  2017;109(5):311–323.
2
Servey J, Reamy B, Hodge J. Clinical presentations of parv...

ADDITIONAL READING

  • Barah F, Whiteside S, Batista S, et al. Neurologic aspects of human parvovirus B19 infection: a systematic review. Rev Med Virol.  2014;24:154–168.

  • Bihari C, Rastogi A, Saxena P...

CODES

ICD10

  • B34.3 Parvovirus infection, unspecified

  • B08.3 Erythema infectiosum [fifth disease]

ICD9

  • 079.83 Parvovirus B19

  • 057.0 Erythema infectiosum (fifth disease)

SNOMED

  • 186748004 Parvovirus infection

  • 34730...

CLINICAL PEARLS

  • Parvovirus B19 infection is usually a benign, self-limited illness with no long-term effects.

  • Patients are no longer infectious by the time the rash of erythema infectiosum, a “slapped ...

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