Bullous pemphigoid (BP) is a chronic, acquired autoimmune subepidermal blistering skin disorder caused by linear deposition of autoantibodies against the epithelial basal membrane zo...
BP occurs sporadically without any obvious trigger factor.
Prodromal nonbullous phase: mild to severe pruritus, associated with excoriated, eczematous, and often urticarial plaques
Muco...
Discontinue trigger factors.
Secondary infection should be treated aggressively with systemic antibiotics.
Depending on the extent of the disease, consultation with dentistry, ...
Taper medication when disease is stable and control side effects.
Perform periodic skin examination for new lesions.
Frequent bacterial cultures o...
Feliciani C, Joly P, Jonkman MF, et al. Management of bullous pemphigoid: the European Dermatology Forum consensus in collaboration with the European Academy of Dermatolo...
77090002 Bullous pemphigoid (disorder)
402440008 oral mucous membrane involvement by bullous pemphigoid (disorder)
403629000 drug-induced bullous pemphigoid (di...
Tense bullae differentiate the lesions of bullous pemphigoid from the flaccid bullae of pemphigus vulgaris.
Low doses of potent topical steroid have been shown to be just as effective a...
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Bullous pemphigoid. A. The skin shows multiple tense bullae on an erythematous base and erosions, distributed primarily on the medial thighs and trunk. B. A subepidermal blister has an edematous papillary dermis as its base. The roof of the blister consists of the intact, entire epidermis, including the stratum basalis. Inflammatory cells, fibrin, and fluid fill the blister.
Elder AD, Elenitsas R, Johnson BL, et al: Synopsis and Atlas of Lever's Histopathology of the Skin. Lippincott Williams & Wilkins, Philadelphia, 1999, p 2, clin. fig. IA1; p 163, clin. fig. IVE3; p 167,
Bullous pemphigoid. A. The skin shows multiple tense bullae on an erythematous base and erosions, distributed primarily on the medial thigh...
Bullous pemphigoid.
Dale Berg, Katherine Worzala, Atlas of Adult Physical Diagnosis. Philadelphia: Lippincott Williams & Wilkins, 2006.
Dale Berg, Katherine Worzala, Atlas of Adult Physical Diagnosis. Philadelphia: Lippincott Williams & Wilkins, 2006...
<bold><italic>Figure 14.79.</bold></bold> Bullous pemphigoid.
Pathogenetic mechanisms of blister formation in bullous pemphigoid. A circulating antibody to an apparently normal glycoprotein - BP antigen - in the lamina lucida precipitates the pathogenetic events in bullous pemphigoid. (A) Antigen-antibody union activates complement, and the anaphylatoxins C3a and C5a are produced. These degranulate mast cells, resulting in release of eosinophilic chemotactic factor. (B and C) The tissue-damaging substances of eosinophilic granules cause vesicle format...
Pathogenetic mechanisms of blister formation in bullous pemphigoid. A circulating antibody to an apparently normal glycoprotein - BP antig...