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Pemphigoid Gestationis

Michelle D. Marieni, MD and Tiffany A. Moore Simas, MD, MPH, MEd Reviewed 06/2018
 


BASICS

Uncommon pregnancy-associated autoimmune bullous disease 

DESCRIPTION

  • Pemphigoid gestationis (PG) is a rare dermatopathic autoimmune-mediated, self-limited eruption most often occurring during mi...

DIAGNOSIS

HISTORY

  • Current pregnancy or recent delivery

  • Lesions begin as itchy periumbilical papules that spread to trunk, back, buttocks, and arms.

  • Face, scalp, palms, soles, and mucous membranes usually...

TREATMENT

  • Goal is to reduce pruritic lesions and discomfort.

  • Treat mild disease with oral antihistamines and topical steroids.

  • Treat more involved cases primarily with systemic corticosteroids.

  • Severe ca...

ONGOING CARE

PATIENT EDUCATION

  • Benign disease; no permanent adverse sequelae (e.g., scarring) in the absence of secondary infection; usually resolves after delivery. Postinflammatory hyperpigmentation ...

REFERENCES

1
Chi CC, Wang SH, Charles-Holmes R, et al. Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes. Br J Dermatol.  2009;160(6):1222–12...

ADDITIONAL READING

  • Amber KT, Murrell DF, Schmidt E, et al. Autoimmune subepidermal bullous diseases of the skin and mucosae: clinical features, diagnosis, and management [published online ahead of pri...

SEE ALSO

Algorithm: Genital Ulcers 

CODES

ICD10

  • O26.40 Herpes gestationis, unspecified trimester

  • O26.42 Herpes gestationis, second trimester

  • O26.43 Herpes gestationis, third trimester

  • O26.41 Herpes gestationis, first trimester

ICD9

  • 646.83 Oth...

CLINICAL PEARLS

  • Rare autoimmune bullous dermatosis of pregnancy and the puerperium

  • Originally named herpes gestationis on the basis of the morphologic herpetiform features. PG is not associated with he...

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