A group of monogenic disorders that results in renal cyst development
The most frequent are two genetically distinct conditions: autosomal dominant polycystic kidney disease (ADPKD) a...
Positive family history (15% are de novo mutations)
Flank pain: 60%
HTN: 50% aged 20 to 34 years; 100% with ESKD
Presymptomatic screening of ADPKD is not cu...
HTN: moderate sodium restriction, weight control, and regular exercise
Medications: ACE inhibitors; angiotensin receptor blockers (ARBs)
Pain: narcotics and other analgesics; b...
Chapman AB, Bost JE, Torres VE, et al. Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2012;7(3):479–486. [View A...
Q61.3 Polycystic kidney, unspecified
Q61.19 Other polycystic kidney, infantile type
Q61.2 Polycystic kidney, adult type
Q61.11 Cystic dilatation of collecting ducts
753.12 Polycystic kidney...
Most PKD patients eventually develop ESKD. No specific treatment has been proven to prevent EKRD, but hydration and control of BP are reasonable goals and should be started soon.
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