Polycythemia vera (PV) is a myeloproliferative clonal stem cell disorder marked by increased production of red blood cells (erythrocytosis) with excessive erythroid, myeloid, and meg...
Patients may be asymptomatic or present with nonspecific complaints, including fatigue, malaise, weight loss, sweating, and subjective weakness.
Erythromelalgia (burning pain of feet/h...
Risk factors: Patients >60 years with history of thrombosis are high risk. Those who are <60 years with no history of thrombosis but with elevated platelets (>150,00...
Avoid high-sodium diet; can cause fluid retention
Avoid iron sup...
Passamonti F. How I treat polycythemia vera. Blood. 2012;120(2):275–284. [View Abstract on OvidMedline]
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D45 Polycythemia vera
109992005 Polycythemia vera (clinical)
127066000 Familial polycythemia vera
44865000 Secondary polycythemia
389147003 Relative polycythemia
127062003 Erythrocytosis
36...
Erythrocytosis: Hgb >16.5 g/dL in men, >16.0 g/dL in women
JAK2 mutations are an important component of myeloproliferative disorders.
Bone marrow biopsy can help in diagnosis showi...
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