Polycythemia vera (PV) is a chronic myeloproliferative clonal stem cell disorder marked by increased production of red blood cells (erythrocytosis) with excessive erythroid, myeloid,...
Patients may be asymptomatic or present with nonspecific complaints, including fatigue, malaise, weight loss, sweating, and subjective weakness.
Erythromelalgia (burning pain of feet/h...
Risk factors: Patients >60 years with history of thrombosis are high risk. Those who are <60 years with no history of thrombosis but with elevated platelets (>150,00...
Avoid high-sodium diet; can cause fluid retention
Avoid iron sup...
Passamonti F. How I treat polycythemia vera. Blood. 2012;120(2):275–284. [View Abstract on OvidMedline]
Tefferi A, Fonseca R. Selective serotonin reuptake inhibitors are effec...
D45 Polycythemia vera
D75.1 Secondary polycythemia
238.4 Polycythemia vera
289.0 Polycythemia, secondary
109992005 Polycythemia vera (disorder)
127062003 Erythrocytosis (disorder)
Erythrocytosis: Hgb >16.5 g/dL in men, >16.0 g/dL in women
JAK2 mutations are an important component of myeloproliferative disorders.
Bone marrow biopsy can help in diagnosis showi...
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