PLS is a clinical diagnosis of exclusion.
Clinical diagnosis is defined as UMN only involvement for at least 4 years from symptom onset.
Multiple diagnostic criteria exist. Consensus diagnosti...
Mainly supportive care
Nursing home placement or hospice at end stage
Discussion of advance directives and completion of ...
PLS has not been shown to shorten life expectancy.
Median survival after diagnosis is 19 years.
An older age at onset is associated with rapid decline in functional status.
PLS affects only UMNs.
Onset is usually asymmetric spasticity in the lower extremities. The patient may present complaining of stiffness, slowness, clumsiness, falls, balance issues, an...
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