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Prostate Cancer

Alex M. Hennessey, MD, Sara L. Valente, MD and Joseph R. Wagner, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • The prostate is a male reproductive organ that contributes seminal fluid to the ejaculate.

  • The prostate gland is about the size of a walnut, averaging 20 to 25 g in volume in an adult...

DIAGNOSIS

HISTORY

  • Inquire about family history of CaP, symptoms of bladder outlet obstruction, and other voiding symptoms.

  • Anorexia and weight loss, bone pain or neurologic deficits from spinal cord com...

TREATMENT

Treatment options include (4): 
  • Watchful waiting: monitoring with expectation to provide palliation with symptoms

  • Active surveillance: close monitoring of PSA, DRE, and repeat biopsy at regula...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Prostatectomy: PSA and DRE are recommended at regular intervals. PSA threshold-defining biochemical recurrence is evolving; however, recent data suggest a cutoff ...

REFERENCES

2
Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the d...

ADDITIONAL READING

  • James ND, de Bono JS, Spears MR, et al; for STAMPEDE Investigators. Abiraterone for prostate cancer not previously treated with hormone therapy. N Engl J Med.  2017;377(4):338–...

CODES

ICD10

C61 Malignant neoplasm of prostate 

ICD9

185 Malignant neoplasm of prostate 

SNOMED

  • 399068003 Malignant tumor of prostate (disorder)

  • 399490008 Adenocarcinoma of prostate

  • 254900004 Carcinoma of pr...

CLINICAL PEARLS

  • Prostate cancer is clinically diverse, ranging from low-risk/indolent disease to high-risk/aggressive disease.

  • Most men with CaP are asymptomatic.

  • The use of PSA for CaP screening is con...

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