Protein C is a vitamin K–dependent factor synthesized, in an inactive form, by the liver.
Activated protein C inhibits generation of thrombin by inactivating factors Va and VIIIa, usi...
Recurrent VTE
VTE at <40 years of age
Thrombosis in unusual locations (e.g., mesentery, sagittal sinus, portal vein)
Family history of thrombosis or spontaneous abortion
Often has othe...
Individuals with PCD should be educated regarding signs and symptoms of VTE.
Women with any of the following history should avoid estradiol-...
Warfarin requires periodic monitoring of the INR to maintain a range of 2 to 3 (monthly, after initial stabilization).
LMWH is the treatment of c...
76407009 Protein C deficiency disease (disorder)
439002002 Thrombophilia due to acquired protein C deficienc...
Testing for heritable causes of thrombophilia in unselected patients presenting with a first episode of VTE (provoked or unprovoked) is not indicated.
Screening, and therefore prophylac...
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