Protein S is a vitamin K–dependent glycoprotein, produced mainly in the liver that acts as a cofactor for protein C. It is also produced by megakaryocytes and endothelial cells.
Unprovoked VTE at age <50 years
VTE with a strong family history of VTE or known familial protein S deficiency
VTE in unusual sites a...
Routine anticoagulation for asymptomatic patients with protein S deficiency is not recommended.
Antithrombotic therapy recommendations for patients with protein S deficiency c...
Warfarin requires periodic (monthly after initial stabilization) monitoring of the INR.
Periodic measurement of INR to maintain a range of 2 to 3
1563006 protein S deficiency disease (disorder)
439125003 Thrombophilia due to acquired protein S deficiency
Asymptomatic patients with protein S deficiency do not require prophylactic anticoagulation because the risk of thrombosis is low; asymptomatic patients do not require anticoagulation.
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