Skip to main content

Protein S Deficiency

Oscar Cabrera-Marante, MD, Tais Gonzalez Pessolani, MD and Gonzalo Carreño-Tarragona, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Protein S is a vitamin K–dependent glycoprotein, produced mainly in the liver that acts as a cofactor for protein C.

  • Protein C becomes activated when thrombin binds to the endothelial...

DIAGNOSIS

HISTORY

Any inherited thrombophilias should be suspected in: 
  • Unprovoked VTE at age <50 years

  • VTE with a strong family history of VT or known familial protein S deficiency

  • VTE in unusual site...

TREATMENT

GENERAL MEASURES

  • Routine anticoagulation for asymptomatic patients with protein S deficiency is not recommended.

  • Antithrombotic therapy recommendations for patients with protein S deficiency c...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • Warfarin requires periodic (monthly after initial stabilization) monitoring of the INR.

  • Periodic measurement of INR to maintain a range of 2 to 3

  • ...

REFERENCES

1
Moll S. Thrombophilias—practical implications and testing caveats. J Thromb Thrombolysis.  2006;21(1):7–15. [View Abstract on OvidMedline]
2
Bick RL. Prothrombin G20210A mutation, anti...

CODES

ICD10

D68.59 Other primary thrombophilia 

ICD9

289.81 Primary hypercoagulable state 

SNOMED

  • 1563006 protein S deficiency disease (disorder)

  • 439125003 Thrombophilia due to acquired protein S deficiency

  • ...

CLINICAL PEARLS

  • Asymptomatic patients with protein S deficiency do not require prophylactic anticoagulation because the risk of thrombosis is low; asymptomatic patients do not require anticoagulation.

  • ...

Subscribe to Access Full Content

Sign Up for a 10-Day Free Trial

Sign up for a 10-day FREE Trial now and receive full access to all content.

×