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Proteinuria

Samantha Carroll, MD and Christian Soeharsono, MD Reviewed 04/2024
 


BASICS

DESCRIPTION

  • Proteinuria: Urinary protein excretion of >150 mg/day.

  • Nephrotic-range proteinuria: Urinary protein excretion of ≥3.5 g/day; also called heavy proteinuria

PEDIATRIC CONSIDERATIONS
  • Pr...

DIAGNOSIS

HISTORY

  • Fever

  • Frothy/foamy urine

  • Change in urine output

  • Blood- or cola-colored urine

  • Recent weight change

  • History of UTIs

  • Dysuria, flank pain

  • Swelling

  • Rule out systemic illness: diabetes, heart failu...

TREATMENT

  • Treat any identified underlying etiology

  • BP goal for both diabetic and nondiabetic is ≤140/90 mm Hg (5)[C].

  • Proteinuria goal is <0.5 g/day (6)[A].

  • BP goal of 130/80 mm Hg for patients with...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

All patients with persistent proteinuria should be followed with serial BP checks, UA, and renal function tests. 

DIET

  • Restrict dietary sodium to ...

REFERENCES

1
Mazaheri M, Assadi F. Simplified algorithm for evaluation of proteinuria in clinical practice: how should a clinician approach? Int J Prev Med. 2019;10:35. doi: 10.4103/ijpvm.IJPVM_557_18.
...

CODES

ICD10

  • R80.9 Proteinuria, unspecified

  • R80.2 Orthostatic proteinuria, unspecified

  • R80.1 Persistent proteinuria, unspecified

  • R80.8 Other proteinuria

SNOMED

  • 29738008 Proteinuria (finding)

  • 32482005 Orthosta...

CLINICAL PEARLS

  • Transient and orthostatic proteinuria are benign conditions that do not convey a poor prognosis.

  • Proteinuria >2 g/day likely represents glomerular malfunction and warrants a nephrolo...

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