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Reactive Arthritis (Reiter Syndrome)

Douglas W. MacPherson, MD, MSc–CTM, FRCPC Reviewed 06/2019
 


BASICS

Reiter syndrome is a seronegative, multisystem, inflammatory disorder classically involving joints, the eye, and the lower genitourinary (GU) tract. Axial joint (e.g., spine, sacroiliac joints)...

DIAGNOSIS

  • Clinical presentation with joint, eye, and GU inflammation (“classic triad”) and negative serologic testing for rheumatoid factor

  • Classic symptoms not always present

  • HLA-B27 testing is not req...

TREATMENT

GENERAL MEASURES

Treatment is determined by symptoms. 
  • Conjunctivitis does not require specific treatment.

  • Iritis requires treatment.

  • Mucocutaneous lesions do not require treatment.

  • Physical ther...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Activity modification until joint inflammation subsides 

Patient Monitoring

Monitor clinical response to anti-inflammatory drugs. Observe for complications, particu...

REFERENCES

1
Selmi C, Gershwin ME. Diagnosis and classification of reactive arthritis. Autoimmun Rev.  2014;13(4–5):546–549. [View Abstract on OvidMedline]
2
Zeidler H, Hudson AP. New insights into ...

ADDITIONAL READING

  • Boring MA, Hootman JM, Liu Y, et al. Prevalence of arthritis and arthritis-attributable activity limitation by urban-rural county classification—United States, 2015. MMWR Morb Morta...

CODES

ICD10

  • M02.30 Reiter’s disease, unspecified site

  • M02.39 Reiter’s disease, multiple sites

ICD9

  • 099.3 Reiter’s disease

  • 711.10 Arthropathy associated with Reiter's disease and nonspecific urethritis, sit...

CLINICAL PEARLS

  • Diagnosis of Reiter syndrome is based on the clinical presentation of the classic triad of joint, eye, and GU inflammation and negative serologic testing for rheumatoid factor (signs a...

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