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Reactive Arthritis (Reiter Syndrome)

Laura E Marsh, MD Reviewed 04/2024
 


BASICS

Reiter syndrome is a seronegative, multisystem, inflammatory disorder classically involving joints, the eye, the lower genitourinary (GU) tract, and the skin. It is an inflammatory arthritis th...

DIAGNOSIS

  • Clinical presentation with joint, eye, and GU inflammation (“classic triad”) and negative serologic testing for rheumatoid factor.

  • Classic symptoms are not always present.

  • HLA-B27 testing is n...

TREATMENT

GENERAL MEASURES

Treatment is determined by symptoms. 
  • Conjunctivitis does not require specific treatment.

  • Iritis requires treatment.

  • Mucocutaneous lesions do not require treatment.

  • Physical ther...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Activity modification until joint inflammation subsides. 

Patient Monitoring

Monitor clinical response to anti-inflammatory medications. Observe for complications, ...

REFERENCES

1
Schmitt SK. Reactive arthritis. Infect Dis Clin North Am. 2017;31(2):265-277.
2
Jubber A, Moorthy A. Reactive Arthritis: a clinical review. J R Coll Physicians Edinb. 2021;51(3):288-297J.

SEE ALSO

Ankylosing Spondylitis; Arthritis, Psoriatic; Behçet Syndrome 

CODES

ICD10

  • M02.30 Reiter’s disease, unspecified site

  • M02.39 Reiter’s disease, multiple sites

SNOMED

  • 67224007 Reiter’s disease (disorder)

  • 415141001 Post-genitourinary infection Reiter's disease (disorder)

  • 4...

CLINICAL PEARLS

  • Diagnosis of reactive arthritis is based on the clinical presentation of the classic triad of joint, eye, and GU inflammation and negative serologic testing for rheumatoid factor (sign...

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