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Renal Cell Carcinoma

Sonali Harchandani, MBBS, Kriti Mittal, MD, MS and Jennifer Yates, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Renal cell carcinoma (RCC) arises from the parenchyma of the kidney (as opposed to urothelial cancer, which arises from the renal pelvis/calyces). According to SEER, there is estimat...

DIAGNOSIS

HISTORY

  • >60% of RCCs are incidental findings in asymptomatic patients due to increased use of ultrasound, CT scan, and MRI.

  • In more advanced disease, subjective symptoms can include gross h...

TREATMENT

Among small (<4 cm) renal masses, approximately 20% are benign, 60% represent indolent variants of RCC, and only 20% are potentially aggressive tumors. 

MEDICATION

First Line

  • Early cytoreduc...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • The majority of recurrences will occur in the first 3 years after treatment.

  • Radiographic follow-up is based on risk as established in the AUA gu...

REFERENCES

1
Choueiri TK, Halabi S, Sanford BL, et al. Cabozantinib versus sunitinib as initial targeted therapy for patients with metastatic renal cell carcinoma of poor or intermediate risk: the alli...

CODES

ICD10

  • C64.9 Malignant neoplasm of unsp kidney, except renal pelvis

  • C64.1 Malignant neoplasm of right kidney, except renal pelvis

  • C64.2 Malignant neoplasm of left kidney, except renal pelvis

  • C64 Mali...

CLINICAL PEARLS

  • RCC; most found incidentally during radiologic studies

  • At presentation, up to 1/3 of patients with RCC have metastatic disease.

  • Surgery is curative in most patients with nonmetastatic RC...

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