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Restless Legs Syndrome

Denise Sharon, MD, PhD, FAASM and Rochelle Zak, MD Reviewed 06/2022
 


BASICS

DESCRIPTION

  • Sensorimotor disorder consisting of a strong, nearly irresistible urge to move the limbs. Legs are usually affected initially, but may involve arms or other body parts.

  • The symptoms (...

DIAGNOSIS

  • Clinical, based on Hx, “difficult to describe”

  • All criteria must be met for RLS diagnosis (3)[C]:

    • An urge to move the legs, usually accompanied by or thought to be caused by uncomfo...

TREATMENT

GENERAL MEASURES

  • If iron insufficient, supplement (2)[C]:

    • 325 mg FeSO4 in the eve+ 100 mg VIt C

    • Repletion requires months till serum ferritin >75 ng/mL and Tsat >16%.

  • Daily exercise; avoi...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • At 1-4-w intervals until stable and then annually

  • If taking iron, reassess iron stores, at least ferritin.

  • If status changes, assess for augmentat...

REFERENCES

1
Picchietti  DL, Hensley  JG, Bainbridge  JL, et al; for International Restless Legs Syndrome Study Group. Consensus clinical practice guidelines for the diagnosis a...

ADDITIONAL READING

  • Garcia-Borreguero  D, Cano-Pumarega  I. New concepts in the management of restless legs syndrome. BMJ.  2017;356:j104. [View Abstract on OvidMedline]...

SEE ALSO

  • Periodic Limb Movement Disorder (PLMD)

  • International Restless Legs Syndrome Study Group: irlssg.org

CODES

ICD10

G25.81 Restless legs syndrome 

SNOMED

32914008 Restless legs (disorder) 

CLINICAL PEARLS

  • Insomnia is often a symptom of RLS.

  • Antidepressants, antipsychotics, antiemetics, and sedating antihistamines can trigger or worsen RLS.

  • Severity and change in Sx can be monitored using ...

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