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Rhabdomyosarcoma

Bryan G. Beutel, MD and Charles R. Marchese, MS Reviewed 04/2024
 


BASICS

DESCRIPTION

Rhabdomyosarcoma (RMS) is a malignant soft tissue tumor presumed to originate from a mesenchymal cell line shared with striated skeletal muscle 
Occurs mainly as primary malignancy bu...

DIAGNOSIS

Thorough history and physical examination necessary, but typically requires molecular genetic, immunohistochemical, and/or structural techniques to confirm diagnosis of RMS 

HISTORY

Initial pr...

TREATMENT

  • Spans surgical resection, radiation, and chemotherapy

  • Treatment should be performed by interdisciplinary team that includes oncologist, surgeon, and radiologist

GENERAL MEASURES

The development...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Physical examination and imaging surveillance for the first 5 years (CT/MRI/x-ray) to assess for recurrence, metastatic disease, or development of secondary malig...

REFERENCES

1
Gallagher KD, van Heerden W, Said-Al-Naief N, et al. Molecular profile of head and neck rhabdomyosarcomas: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol...

ADDITIONAL READING

Leiner J, Le Loarer F. The current landscape of rhabdomyosarcomas: an update. Virchows Arch. 2020;476(1):97—108.  

CODES

ICD10

  • C49.9 Malignant neoplasm of connective and soft tissue, unsp

  • C49.0 Malignant neoplasm of connective and soft tissue of head, face and neck

  • C49.5 Malignant neoplasm of connective and soft tiss...

CLINICAL PEARLS

  • RMS more common in children but can develop in adults, the latter having higher mortality

  • Genetic disorders and congenital syndromes increase risk of RMS.

  • If a localized tumor is identif...

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