A potentially life-threatening drug-induced syndrome that results from synaptic increase in serotonin (5-hydroxytryptamine [5-HT]) concentrations and stimulation of peripheral and CN...
Serotonin syndrome is a clinical diagnosis.
Hunter Toxicity Criteria Decision Rules (3) aid in the diagnosis of clinically significant serotonin toxicity (sensitivity, 84%; specificity, 97%)....
Discontinuation of all serotonergic agents regardless of severity.
Supportive care is the mainstay of therapy: administrating oxygen and aggressive IV fluids, continuous cardiac monitoring, m...
In mild cases address risks and benefits of restarting offending agents. Serotonergic medications need to be titrated slowly, and patients must have close outpati...
Mas Serrano M, Pérez-Sánchez JR, Portela Sánchez S, et al. Serotonin syndrome in two COVID-19 patients treated with lopinavir/ritonavir. J Neurol Sci. 2020;415...
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