A potentially life-threatening drug-induced syndrome that results from synaptic increase in serotonin (5-hydroxytryptamine [5-HT]) concentrations and stimulation of peripheral and CN...
Serotonin syndrome is a clinical diagnosis.
Hunter Toxicity Criteria Decision Rules (3) aid in the diagnosis of clinically significant serotonin toxicity (sensitivity, 84%; specificity, 97%)....
Supportive care is the mainstay of therapy: administrating oxygen and aggressive IV fluids, continuous cardiac monitoring, monitoring urine output, and stabilizing vital signs.
Benzodiazepine...
In mild cases address risks and benefits of restarting offending agents. Serotonergic medications need to be titrated slowly, and patients must have close outpati...
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