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Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)

Jarrett Keller Sell, MD FAAFP AAHIVS Reviewed 05/2023
 


BASICS

DESCRIPTION

  • A rare disorder of the skin that is characterized by the abrupt onset of painful, edematous, and erythematous lesions (papules, plaques, or nodules) (1). The lesions are often accom...

DIAGNOSIS

HISTORY

  • The most frequent symptom is fever, which may precede the cutaneous manifestations by several days to weeks and can be present throughout the entire episode.

  • Patients may report an ant...

TREATMENT

  • If untreated, can remain for weeks to months

  • Without therapeutic intervention, the cutaneous lesions and dermatosis-related symptoms eventually resolve in cases of the classic subtype.

  • In case...

ONGOING CARE

PROGNOSIS

  • In the classic subtype, symptoms may remit or show resolution without therapeutic intervention.

  • Successful management of the cancer in the malignancy-associated subtype occasional...

REFERENCES

1
Nelson  CA, Stephen  S, Ashchyan  HJ, et al. Neutrophilic dermatoses: pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet disease. J Am Acad...

ADDITIONAL READING

  • Chan  MP, Duncan  LM, Nazarian  RM. Subcutaneous Sweet syndrome in the setting of myeloid disorders: a case series and review of the literature. J Am Acad...

CODES

ICD10

L98.2 Febrile neutrophilic dermatosis [Sweet] 

SNOMED

  • 84625002 Acute febrile neutrophilic dermatosis (disorder)

  • 403216007 Sweet’s disease following infection (disorder)

  • 402747005 Sweet’s diseas...

CLINICAL PEARLS

  • Consider Sweet syndrome in patients with abrupt onset of fever and asymmetric, erythematous, tender papules, plaques, or nodules.

  • Skin biopsy demonstrates neutrophilic infiltrates in th...

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