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Synovitis, Pigmented Villonodular

Katyayini Aribindi, MD, Adrian DaSilva-DeAbreu, MD and Jennifer L. Swails, MD Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Pigmented villonodular synovitis (PVNS), also known as tenosynovial giant cell tumor, is a benign proliferative and inflammatory disease associated with synovial hypervascularity.

  • Cla...

DIAGNOSIS

HISTORY

  • Large joints, knee/hip are most commonly affected.

  • Less common: ankle, shoulder/elbow, TMJ, and spine. Some older studies claim the foot as another commonly affected joint; however, mo...

TREATMENT

GENERAL MEASURES

  • Surgical resection (3,4)[B]

    • First-line treatment

    • Complete synovectomy by open surgical procedure for DPVNS.

    • Arthroscopic partial synovectomy for LPVNS

    • Patients with large poplite...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Close follow-up for recurrence and progression of disease 

PROGNOSIS

  • Patients with recurrent disease usually present with more extensive involvement leading to redu...

REFERENCES

1
Murphey MD, Rhee JH, Lewis RB, et al. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics.  2008;28(5):1493–1518. [View Abstract on OvidMedline]
2
Temponi...

ADDITIONAL READING

  • Al-Nakshabandi NA, Ryan AG, Choudur H, et al. Pigmented villonodular synovitis. Clin Radiol.  2004;59(5):414–420.

  • Aurégan JC, Klouche S, Bohu Y, et al. Treatment of pigmented vi...

CODES

ICD10

  • M12.20 Villonodular synovitis (pigmented), unspecified site

  • M12.259 Villonodular synovitis (pigmented), unspecified hip

  • M12.269 Villonodular synovitis (pigmented), unspecified knee

  • M12.279 Vil...

CLINICAL PEARLS

  • PVNS is characterized by synovial inflammation and hemosiderin deposition with unknown etiology. However, it has been linked to trauma with subsequent joint hemorrhage.

  • There are two ty...

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