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Synovitis, Pigmented Villonodular

Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Pigmented villonodular synovitis (PVNS), also known as tenosynovial giant cell tumor (TGCT), is a benign proliferative and inflammatory disease associated with synovial hypervascular...

DIAGNOSIS

HISTORY

  • Knee joints are most commonly affected, followed by the foot. Previously, data suggested the hip was more common than the foot, but that does not seem to be the case. Involvement of t...

TREATMENT

GENERAL MEASURES

  • Surgical resection (3),(4),(5)[A]

    • First-line treatment

    • Complete synovectomy by open surgical procedure for DPVNS.

    • Arthroscopic partial synovectomy for LPVNS

    • Patients with large...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Close follow-up for recurrence and progression of disease 

PROGNOSIS

  • Patients with recurrent disease usually present with more extensive involvement leading to redu...

REFERENCES

1
Murphey MD, Rhee JH, Lewis RB, et al. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics.  2008;28(5):1493–1518. [View Abstract on OvidMedline]
2
Temponi...

ADDITIONAL READING

  • Al-Nakshabandi NA, Ryan AG, Choudur H, et al. Pigmented villonodular synovitis. Clin Radiol.  2004;59(5):414–420. [View Abstract on OvidMedline]

  • Aurégan JC, Klouche S, Bohu Y, e...

CODES

ICD10

  • M12.20 Villonodular synovitis (pigmented), unspecified site

  • M12.259 Villonodular synovitis (pigmented), unspecified hip

  • M12.269 Villonodular synovitis (pigmented), unspecified knee

  • M12.279 Vil...

CLINICAL PEARLS

  • PVNS is characterized by synovial inflammation and hemosiderin deposition with unknown etiology. However, it has been linked to trauma with subsequent joint hemorrhage.

  • There are two ty...

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